It Takes Two (T2)

The overarching goal of “It Takes Two” is to test the efficacy of a promising couples-focused HIV prevention intervention to reduce HIV transmission risk among trans women and their primary partners by integrating biomedical and behavioral risk reduction strategies to help couples choose the most appropriate HIV prevention plan for their relationship. We will assess the intervention effects on a measure of dyadic HIV transmission risk, which is a Composite Risk for HIV (CR-HIV). Guided by Interdependence Theory, the Gender Minority Stress Model, and the Gender Affirmation model, the project is driven and being developed by the needs and experiences of trans women of color in the Bay Area.

The project aims to:

  • Evaluate the efficacy of a couples intervention on CR-HIV compared to an enhanced standard of care control condition
  • Assess the effects of the intervention on theory-based mediators
  • Explore partner gender and couple HIV status as moderators of the effect of the intervention on CR-HIV

It Takes Two Team

  • Principal Investigators: Jae Sevelius, PhD (CAPS, UCSF); Kristi Gamarel, PhD (University of Michigan); Don Operario, PhD (Brown University)
  • Co-Investigators: Torsten Neilands, PhD (CAPS, UCSF); Mallory Johnson, PhD (CAPS, UCSF) ; Lynae Darbes, PhD (University of Michigan); Tooru Nemoto, PhD (Public Health Institute)
  • Co-Investigator and Project Director: Rachel L. Kaplan, PhD, MPH (Ob/Gyn, UCSF)
  • Project Coordinator: Akira Jackson
  • Peer Health Counselor: Breonna McCree
  • Data Manager: Deepalika Chakravarty, MS
  • Clinical Lead: David Olem, MFT
  • Research Assistant and Study Phlebotomist: Carla Clynes

Contact

Rachel L. Kaplan, PhD, MPH
Co-Investigator and Project Director
[email protected]

(415) 476-5895