The overarching goal of this program project (P01) is to evaluate novel and strategic interventions to reduce the burden of malaria and improve HIV outcomes among children and pregnant women, the populations most affected by the overlap of these diseases. We hypothesize that treatment with HIV protease inhibitors (PIs) will lower the incidence of malaria and consequent morbidity in HIV+ children and pregnant women compared to those treated with standard antiretroviral treatment.
The goal of this study is to develop a preliminary understanding of the social and cultural context in which HIV serodiscordant couples in Kenya are making the decision to become pregnant.
The specific aims of this study are:
To explore the motivations for conception, understanding the risk of HIV transmission, and the decisionmaking process of serodiscordant couples desiring pregnancy.
To assess the acceptability of:
Limiting unprotected intercourse to the fertile
The Ryan White HIV/AIDS Treatment Modernization Act (a reauthorization of the original Ryan White CARE Act) changed the formulas used to distribute funding to states and cities in the US. The case counts used to allocate the awards shifted from using only AIDS cases to using both HIV (non-AIDS) and AIDS cases.
In this project we will develop, pilot and evaluate a curriculum for improving HIV research counseling and testing (HRCT) skills among staff working in international prevention and treatment clinical trials.
This study has three components:
Describe the strategies HIV rapid test counselors use to manage multiple roles during the test session.
Develop a computer assisted survey that is self-administered by the client before they see the counselor (PalmPal).
Enhance counselor training and supervision using time charts.
This pilot study will determine the acceptability and translatability of PalmPal, an innovative structural intervention we designed to improve the process of HIV test counseling. PalmPal is a ten minute risk assessment questionnaire that is self administered by the client using a handheld computer just prior to the test session. The proposed study will recruit a representative sample of 40 test clients from three test clinics to conduct six focus groups.
The HIV and malaria epidemics inflict the greatest harm in sub-Saharan Africa and overlap significantly. We have recently identified an interaction between acute malaria and false positive HIV EIA test results. This project will investigate this interaction in three of the most common rapid EIA HIV tests used in sub-Saharan Africa among a cohort of 450 HIV-uninfected children aged 2-17 years being followed longitudinally for malaria in Kampala, Uganda as part of a larger, parent study.
Research shows that most men who use multiple types of public venues (bathhouses, sex clubs, parks, bars, etc.) to meet and engage other men reported high-risk behavior. These findings lead us to hypothesize that these high-risk men are a significant proportion of the core of high-risk networks; yet we know little about them. The purpose of this study is to narrow the focus of research to this core, to learn more about their intimate encounters.