This competing renewal application builds upon the success of our project "Relationship Factors and HIV Treatment Adherence" (R01NR010187) also known as the "Duo Project". The parent grant has been successful thus far and the process and findings have informed the aims of this renewal application. Being in a primary Relationship is generally accepted as resulting in logistic and emotional support that provides health- promoting benefits.
The purpose of this K24 application is to support the continuation and proposed expansions of Dr. Mallory Johnson's programs of Mentoring and patient-oriented research (POR) in social and behavioral approaches to optimizing engagement in HIV Care among drug-using populations. the candidate proposes new Mentoring, new research, and additional Training to build competency in Drug abuse research, HCV and liver disease, and advanced research methodologies.
Less than half of individuals living with HIV in the United States are receiving ongoing Care, and only one- quarter have an undetectable Viral Load. The National HIV/AIDS Strategy prioritizes Care and treatment of HIV- infected individuals, yet improvement in Care retention rates is clearly needed. Research on HIV Care has used attendance at primary Care appointments to assess whether Patients are in Care. While Medical visits are necessary, they are not sufficient and do not necessarily reflect a patient's level of Engagement.
The purpose of this project is to (1) provide expanded mentoring of early career clinician- researchers in patient oriented research (POR), and (2) extend his current research program to the study of patient-provider dyads, which will be studied through the integration of research tools into electronic health records (EHR) systems. Dr. Johnson's trainees have emerged as research clinicians interested in conducting POR.
This 5-year research program addresses a neglected topic of HIV prevention research: HIV risks to female migrants in sub-Saharan Africa.
Instrument: HIV treatment adherence self-efficacy scale Scoring: Included in article Reliability or validity: Johnson MO, Neilands TB, Dilworth SE, Morin SF, Remien RH, Chesney MA. The Role of Self-Efficacy in HIV Treatment Adherence: Validation of the HIV Treatment Adherence Self-Efficacy Scale (HIV-ASES). J Behav Med. 2007 Jun 23.
The purpose of The PATH Project is to develop and test an intervention to prepare HIV+ men and women who, based on current treatment guidelines, should be but are not currently taking antiretroviral therapy (ART). The immediate goal of the intervention is to address obstacles to ART uptake.
The Focus Project, funded by the National Center for Complementary and Alternative Medicine at the NIH, is a randomized controlled trial to test the efficacy of a Mindfulness-Based Stress Reduction (MBSR) intervention in reducing HIV treatment side effects and side effect-related distress. The intervention is a standardized series of eight weekly MBSR sessions, two to three hours long, held at the Osher Center for Integrative Medicine. The course also includes daily home assignments of formal and informal meditation practice.
The DUO Project investigates how relationship factors are associated with adherence to antiretroviral therapy (ART). Based on recruitment feasibility and the epidemiology of the HIV epidemic in the San Francisco area, HIV+ seroconcordant and serodiscordant male couples are included in the study’s three phases:
- Phase 1. We conducted a qualitative investigation of relationship dynamics and partner tactics related to HIV medication adherence.
- Phase 2.
The Balance Project is a randomized controlled trial that tests a counseling intervention to help HIV+ men and women achieve an active role in their health care. The intervention is designed to help individuals cope with the challenges of taking medications, deal with side effects, and maintain an active collaboration with their health care providers. We enrolled 250 HIV+ adults taking antiretroviral medications, and will evaluate the impact of the intervention on quality of life and medication adherence. This study involves two phases:
- Phase 1.