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HIV vaccine

Vaccines are among the most powerful and cost-effective disease prevention tools available. A vaccine that could prevent HIV infection or stop progression of the disease would greatly help in the fight against the AIDS pandemic. Vaccines have been pivotal in worldwide smallpox elimination efforts, have nearly eliminated polio and have drastically reduced the incidence of infectious diseases like measles and pertussis in the US. A crucial question is whether a vaccine based on one strain of HIV would be effective for populations in which a different strain is predominant. There are also questions about how an HIV vaccine would protect individuals: the vaccine might not be able to actually prevent infection, but could prevent or delay progression to disease, or simply reduce the infectiousness of people who do become infected with HIV. HIV prevention education and counseling are important components of vaccine programs. Even after the release of a vaccine, there will be an ongoing need for effective behavioral prevention programs. An HIV vaccine will not be a “magic bullet” but it could play an extremely powerful role as part of a package of prevention interventions.

Research Project

ASHA Improving Health and Nutrition of Indian Women with AIDS and Their Children

The overall goal of this study is to enhance the physical and mental health of rural Indian women living with AIDS and their children. We will achieve these goals through the use of trained village women as Accredited Social Health Activists (ASHA) to enhance the health of women and children through improved ART adherence, CD4 levels, and physical and mental health. This Indo-US collaboration between University of California, Los Angeles, University of California, San Francisco and All India Institutes of Medical Sciences (AIIMS) builds on our previous work with rural women living with AIDS and our successful ASHA program. Specific objectives include: Using a 2x2 factorial design, we plan to assess the effects of nutrition training and/or food supplements on primary outcomes for rural women living with AIDS in improving body composition and immune status (CD4 levels) as assessed at 6-, 12- and 18-month follow-up. Examining the effects of the program arms and their interaction on adherence to ART, psychological health, nutritional adequacy, and lipid profile over time.
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Sex education

Sex and HIV education programs have multiple goals: to decrease unintended pregnancy, to decrease STDs including HIV and to improve sexual health among youth. In 2005, almost two-thirds (63%) of all high school seniors in the US had engaged in sex, yet only 21% of all female students used birth control pills before their last sex and only 70% of males used a condom during their last sexual intercourse. In 2000, 8.4% of 15-19 year old girls became pregnant, producing one of the highest teen pregnancy rates in the western industrial world. Persons aged 15-24 had 9.1 million new cases of STDs in 2000 and made up almost half of all new STD cases in the US. There are numerous factors affecting adolescent sexual behavior and use of protection. Some of these factors have little to do with sex, such as growing up in disadvantaged communities, having little attachment to parents or failing at school. Other factors are sexual in nature, such as beliefs, values, perceptions of peer norms, attitudes and skills involving sexual behavior and using condoms or contraception. It is these sexual factors that sex/HIV education programs can potentially affect, thereby impacting behavior. Sex/HIV education programs alone cannot totally reduce sexual risk-taking, but they can be an effective part of a more comprehensive initiative.
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Educación sexual

Los programas educativos sobre la sexualidad y el VIH tienen varias metas: disminuir los embarazos no planeados, reducir las enfermedades de transmisión sexual (ETS) incluyendo la del VIH y mejorar la salud sexual de los jóvenes. En 2005 en los EE.UU., el 63% de todos los alumnos del último año de preparatoria (high school) habían tenido relaciones sexuales, pero sólo el 21 % de las alumnas usaron pastillas anticonceptivas antes del último coito y sólo el 70 % de los varones usaron condón en el último coito. En el 2000, el 8.4 % de las chicas entre 15 y 19 años se embarazaron, produciendo una de las tasas más altas de embarazo adolescente en el mundo occidental industrializado. Casi la mitad de los nuevos casos de ETS en EE.UU. del año 2000 (9.1 millones) se presentaron en jóvenes entre los 15 y los 24 años de edad. Algunos de los numerosos factores que influyen en la conducta sexual y el uso de protección entre los adolescentes tienen poco que ver con las relaciones sexuales, por ejemplo: la crianza en una comunidad desfavorecida, la falta de apego a los padres o el fracaso escolar. Otros factores de naturaleza sexual como las creencias, los valores, las percepciones de normas de los pares, las actitudes y habilidades relacionadas con la conducta sexual y con el uso del condón o de anticonceptivos, son factores en los que los programas de enseñanza potencialmente pueden incidir para generar cambios de conducta. Estos programas no pueden por sí solos eliminar las conductas sexuales riesgosas, pero sí pueden ser una pieza eficaz dentro de una iniciativa integral.
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Stigma

HIV-related stigma is a significant problem globally. HIV stigma inflicts hardship and suffering on people living with HIV and interferes with research, prevention, treatment, care and support efforts. HIV-related stigma refers to negative beliefs, feelings and attitudes towards people living with HIV, their families and people who work with them. HIV stigma often reinforces existing social inequalities based on gender, race, ethnicity, class, sexuality and culture. Stigma against many vulnerable populations who are disproportionately affected by HIV (such as the stigma of homosexuality, drug use, poverty, migration, transgender status, mental illness, sex work and racial, ethnic and tribal minority status) predates the epidemic and intersects with HIV stigma, which compounds the stigma and discrimination experienced by people living with HIV (PLWH) who belong to such groups.1 HIV-related discrimination, also known as enacted HIV stigma, refers to the unfair and unjust treatment of someone based on their real or perceived HIV status. Discrimination also affects family members and friends, caregivers, healthcare and lab staff who care for PLWH. The drivers of HIV-related discrimination usually include misconceptions regarding casual transmission of HIV and pre-existing prejudices against certain populations, behaviors, sex, drug use, illness and death. Discrimination can be institutionalized through laws, policies and practices that unjustly affect PLWH and marginalized groups.