Alan Verkman, MD, PhD

Professor Emeritus

Education
Residency, - Medicine, Brigham & Womens Hospital
M.D., - , Harvard Medical School / HST
M.A., Ph.D., - Physics, Harvard University
S.B., S.B., - Physics, Biology, M.I.T.
Fellowship, - Nephrology, University of California, San Francisco
Websites
Publications

  1. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS. Author Correction: Diabetes insipidus. Nature reviews. Disease primers 2025. PMID: 40467570


  2. Lindgren ES, Yan R, Kuo YM, Gao Q, de Souza Goncalves L, Chen FY, Chan MF, Verkman AS, Cil O, Pasricha ND. Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling. Experimental eye research 2025. PMID: 40112945


  3. Master RJ, Karmakar J, Haggie PM, Anthony-Tan J, Chu T, Verkman AS, Anderson MO, Cil O. High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics. European journal of medicinal chemistry 2024. PMID: 39642691


  4. Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O. Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration. The ocular surface 2024. PMID: 38871216


  5. Ahmadi M, de Souza Goncalves L, Verkman AS, Cil O, Anderson MO. Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria. RSC medicinal chemistry 2024. PMID: 38784456


  6. Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND. Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs). Current ophthalmology reports 2024. PMID: 38756824


  7. Tong XJ, Akdemir G, Wadhwa M, Verkman AS, Smith AJ. Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice. Fluids and barriers of the CNS 2024. PMID: 38178155


  8. Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, Dick DW, Wadas TJ, Joo NS, Wine JJ, Birket S, Fernandez CM, Leung HM, Tearney GJ, Verkman AS, Haggie PM, Scott K, Bartels D, Meyerholz DK, Rowe SM, Liu X, Yan Z, Haber AL, Sun X, Engelhardt JF. Transgenic ferret models define pulmonary ionocyte diversity and function. Nature 2023. PMID: 37730992


  9. Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC medicinal chemistry 2023. PMID: 37974969


  10. Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS. T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37463205


  11. Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. European journal of medicinal chemistry 2023. PMID: 36724632


  12. Lindgren ES, Cil O, Verkman AS, Pasricha ND. Ocular Surface Ion Transport and Dry Eye Disease. Current ophthalmology reports 2022. PMID: 38213468


  13. Cil O, Chu QT, Lee S, Haggie PM, Verkman AS. Small molecule inhibitor of intestinal anion exchanger SLC26A3 for therapy of hyperoxaluria and nephrolithiasis. TO REMOVE 2022. PMID: 35608921


  14. Boecking CA, Walentek P, Zlock LT, Sun DI, Wolters PJ, Ishikawa H, Jin BJ, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE. A simple method to generate human airway epithelial organoids with externally-oriented apical membranes. TO REMOVE 2022. PMID: 35080188


  16. Verkman AS, Galietta LJV. Chloride transport modulators as drug candidates. TO REMOVE 2021. PMID: 34644122


  17. Smith AJ, Akdemir G, Wadhwa M, Song D, Verkman AS. Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake. TO REMOVE 2021. PMID: 34128962


  18. Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. TO REMOVE 2021. PMID: 34100381


  19. Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS. A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats. TO REMOVE 2021. PMID: 33836171


  20. Oak AA, Chhetri PD, Rivera A, Verkman AS, Cil O. Repurposing calcium sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas. JCI insight 2021. PMID: 33400691


  21. Asavapanumas N, Tradtrantip L, Verkman AS. Targeting the complement system in neuromyelitis optica spectrum disorder. Expert opinion on biological therapy 2021. PMID: 33513036


  22. Nalle SC, Barreira da Silva R, Zhang H, Decker M, Chalouni C, Xu M, Posthuma G, de Mazière A, Klumperman J, Baz Morelli A, Fleire SJ, Verkman AS, Trombetta ES, Albert ML, Mellman I. Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation. PloS one 2020. PMID: 33232321


  23. Hara-Chikuma M, Tanaka M, Verkman AS, Yasui M. Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury. Nature communications 2020. PMID: 33168815


  24. Pasricha ND, Smith AJ, Levin MH, Schallhorn JM, Verkman AS. Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport. Translational vision science & technology 2020. PMID: 33117611


  25. Son JH, Phuan PW, Zhu JS, Lipman E, Cheung A, Tsui KY, Tantillo DJ, Verkman AS, Haggie PM, Kurth MJ. 1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants. European journal of medicinal chemistry 2020. PMID: 33092904


  26. Phuan PW, Haggie PM, Tan JA, Rivera AA, Finkbeiner WE, Nielson DW, Thomas MM, Janahi IA, Verkman AS. CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2020. PMID: 32674984


  27. Donowitz M, Turner JR, Verkman AS, Zachos NC. Current and potential future applications of human stem cell models in drug development. The Journal of clinical investigation 2020. PMID: 32452833


  28. Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. The Journal of clinical investigation 2020. PMID: 31961827


  29. Tradtrantip L, Asavapanumas N, Verkman AS. Emerging therapeutic targets for neuromyelitis optica spectrum disorders. Expert opinion on therapeutic targets 2020. PMID: 32070155


  30. Chen X, Lee S, Zhang T, Duan T, Pasricha ND, Schallhorn JM, Levin MH, Koprivica V, Verkman AS. Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2020. PMID: 31934802


  31. Phuan PW, Tan JA, Rivera AA, Zlock L, Nielson DW, Finkbeiner WE, Haggie PM, Verkman AS. Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. Scientific Reports 2019. PMID: 31776420


  32. Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS. Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders. Neuropharmacology 2019. PMID: 31654702


  35. Christ-Crain M, Bichet DG, Fenske WK, Goldman MB, Rittig S, Verbalis JG, Verkman AS. Diabetes insipidus. Nature reviews. Disease primers 2019. PMID: 31395885


  37. Smith AJ, Verkman AS. Rebuttal from Alex J. Smith and Alan S. Verkman. The Journal of physiology 2019. PMID: 31389015


  38. Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. Scientific Reports 2019. PMID: 31311979


  39. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019. PMID: 31299174


  41. Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019. PMID: 31268738


  42. Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin). Bioorganic & medicinal chemistry letters 2019. PMID: 31281021


  43. Smith AJ, Duan T, Verkman AS. Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure. Acta neuropathologica communications 2019. PMID: 31068220


  44. Tradtrantip L, Duan T, Yeaman MR, Verkman AS. CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. Journal of neuroinflammation 2019. PMID: 30851734


  46. Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B. Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019. PMID: 30768374


  47. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cellular and molecular gastroenterology and hepatology 2019. PMID: 30659943


  48. Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS. Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. Journal of neuropathology and experimental neurology 2019. PMID: 30500945


  49. Duan T, Smith AJ, Verkman AS. Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. Journal of neuroinflammation 2018. PMID: 30348195


  50. Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI insight 2018. PMID: 30046015


  51. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2018. PMID: 29903467


  52. Jin BJ, Lee S, Verkman AS. Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Analytical chemistry 2018. PMID: 29779372


  53. Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW. Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis. JCI insight 2018. PMID: 29769447


  54. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. Journal of medicinal chemistry 2018. PMID: 29589443


  55. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS discovery : advancing life sciences R & D 2018. PMID: 29533733


  56. Tradtrantip L, Felix CM, Spirig R, Morelli AB, Verkman AS. Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica. Neuropharmacology 2018. PMID: 29428821


  57. Verkman AS, Yao X, Smith AJ. The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. Journal of cellular and molecular medicine 2018. PMID: 29363875


  58. Smith AJ, Verkman AS. The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018. PMID: 29101220


  59. Verkman AS, Smith AJ, Phuan PW, Tradtrantip L, Anderson MO. The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert opinion on therapeutic targets 2017. PMID: 29072508


  60. Felix CM, Lee S, Levin MH, Verkman AS. Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. Investigative ophthalmology & visual science 2017. PMID: 28873176


  63. Tradtrantip L, Yao X, Su T, Smith AJ, Verkman AS. Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica. Acta neuropathologica 2017. PMID: 28567523


  64. Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F. Mechanisms of Autoantibody-Induced Pathology. Frontiers in immunology 2017. PMID: 28620373


  65. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). Journal of medicinal chemistry 2017. PMID: 28493701


  66. Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochimica et biophysica acta. Biomembranes 2017. PMID: 28477975


  67. Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B. Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease 2017. PMID: 28344130


  68. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. Journal of medicinal chemistry 2017. PMID: 28230981


  69. Jin BJ, Verkman AS. Microfluidic platform for rapid measurement of transepithelial water transport. Lab on a chip 2017. PMID: 28184395


  72. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proceedings of the National Academy of Sciences of the United States of America 2017. PMID: 28049834


  73. Tradtrantip L, Jin BJ, Yao X, Anderson MO, Verkman AS. Aquaporin-Targeted Therapeutics: State-of-the-Field. Advances in experimental medicine and biology 2017. PMID: 28258578


  74. Verkman AS, Tradtrantip L, Smith AJ, Yao X. Aquaporin Water Channels and Hydrocephalus. Pediatric neurosurgery 2016. PMID: 27978530


  75. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Volume 113 of Issue 51. Proceedings of the National Academy of Sciences of the United States of America 2016. PMID: 27940915


  76. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. The Journal of biological chemistry 2016. PMID: 27895116


  77. Jin BJ, Smith AJ, Verkman AS. Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. The Journal of general physiology 2016. PMID: 27836940


  78. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 27871064


  79. Felix CM, Levin MH, Verkman AS. Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. Journal of neuroinflammation 2016. PMID: 27765056


  80. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Translational research : the journal of laboratory and clinical medicine 2016. PMID: 27815136


  81. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography (Ann Arbor, Mich.) 2016. PMID: 27570835


  82. Tradtrantip L, Verkman AS. Aquaporin gene therapy for disorders of cholestasis? Hepatology (Baltimore, Md.) 2016. PMID: 27115396


  83. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Scientific Reports 2016. PMID: 27165276


  84. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. Journal of the American Society of Nephrology : JASN 2016. PMID: 27153921


  85. Yao X, Su T, Verkman AS. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta neuropathologica communications 2016. PMID: 27117475


  86. Esteva-Font C, Jin BJ, Lee S, Phuan PW, Anderson MO, Verkman AS. Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1. Molecular pharmacology 2016. PMID: 26993802


  87. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 26932931


  88. Flores AM, Casey SD, Felix CM, Phuan PW, Verkman AS, Levin MH. Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 26842854


  89. Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. Journal of enzyme inhibition and medicinal chemistry 2016. PMID: 26796863


  90. Hirt L, Fukuda AM, Ambadipudi K, Rashid F, Binder D, Verkman A, Ashwal S, Obenaus A, Badaut J. Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016. PMID: 26767580


  91. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cellular and molecular gastroenterology and hepatology 2016. PMID: 27127798


  92. Smith AJ, Verkman AS. Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections. Biophysical journal 2015. PMID: 26682810


  93. Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2015. PMID: 26474804


  94. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Križaj D. TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015. PMID: 26424896


  95. Jin BJ, Esteva-Font C, Verkman AS. Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab on a chip 2015. PMID: 26159099


  96. Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. Potentiators of Defective ?F508-CFTR Gating that Do Not Interfere with Corrector Action. Molecular pharmacology 2015. PMID: 26245207


  97. Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Molecular pharmacology 2015. PMID: 26174774


  98. Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nature reviews. Gastroenterology & hepatology 2015. PMID: 26122478


  99. Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-?B signalling in keratinocytes and development of psoriasis. Nature communications 2015. PMID: 26100668


  100. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. Journal of neurotrauma 2015. PMID: 25790314


  101. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney international 2015. PMID: 25993324


  102. Smith AJ, Jin BJ, Verkman AS. Muddying the water in brain edema? Trends in neurosciences 2015. PMID: 25980601


  103. Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia 2015. PMID: 25944186


  104. Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. The Journal of biological chemistry 2015. PMID: 25792738


  105. Esteva-Font C, Phuan PW, Lee S, Su T, Anderson MO, Verkman AS. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochimica et biophysica acta 2015. PMID: 25613743


  107. Wang W, Li F, Sun Y, Lei L, Zhou H, Lei T, Xia Y, Verkman AS, Yang B. Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015. PMID: 25573755


  108. Lee S, Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors. MedChemComm 2015. PMID: 26191399


  109. Esteva-Font C, Anderson MO, Verkman AS. Urea transporter proteins as targets for small-molecule diuretics. Nature reviews. Nephrology 2014. PMID: 25488859


  110. Yao X, Derugin N, Manley GT, Verkman AS. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neuroscience letters 2014. PMID: 25449874


  111. Ye L, Hu B, El-Badri F, Hudson BM, Phuan PW, Verkman AS, Tantillo DJ, Kurth MJ. ?F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorganic & medicinal chemistry letters 2014. PMID: 25452003


  112. Malik R, Lewis A, Cree BA, Ratelade J, Rossi A, Verkman AS, Bollen AW, Ralph JW. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle & nerve 2014. PMID: 24862586


  114. Papadopoulos MC, Bennett JL, Verkman AS. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nature reviews. Neurology 2014. PMID: 25112508


  115. Coffman KC, Nguyen HH, Phuan PW, Hudson BM, Yu GJ, Bagdasarian AL, Montgomery D, Lodewyk MW, Yang B, Yoo CL, Verkman AS, Tantillo DJ, Kurth MJ. Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking. Journal of medicinal chemistry 2014. PMID: 25061695


  116. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Some gating potentiators, including VX-770, diminish ?F508-CFTR functional expression. Science translational medicine 2014. PMID: 25101887


  118. Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014. PMID: 24843071


  119. Asavapanumas N, Verkman AS. Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury. Acta neuropathologica communications 2014. PMID: 24758159


  120. Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. Synergy-based small-molecule screen using a human lung epithelial cell line yields ?F508-CFTR correctors that augment VX-809 maximal efficacy. Molecular pharmacology 2014. PMID: 24737137


  121. Akdemir G, Ratelade J, Asavapanumas N, Verkman AS. Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion. Neuroscience letters 2014. PMID: 24717641


  122. Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS. Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids. Biomicrofluidics 2014. PMID: 24738013


  124. Verkman AS, Anderson MO, Papadopoulos MC. Aquaporins: important but elusive drug targets. Nature reviews. Drug discovery 2014. PMID: 24625825


  125. Ratelade J, Smith AJ, Verkman AS. Human immunoglobulin G reduces the pathogenicity of aquaporin-4 autoantibodies in neuromyelitis optica. Experimental neurology 2014. PMID: 24636863


  126. Tradtrantip L, Ko EA, Verkman AS. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS neglected tropical diseases 2014. PMID: 24551253


  127. Smith AJ, Jin BJ, Ratelade J, Verkman AS. Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes. The Journal of cell biology 2014. PMID: 24515349


  128. Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. Journal of neuroinflammation 2014. PMID: 24468108


  129. Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Small-molecule inhibitors of urea transporters. Sub-cellular biochemistry 2014. PMID: 25298345


  130. Esteva-Font C, Jin BJ, Verkman AS. Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24334548


  131. Rama Rao KV, Verkman AS, Curtis KM, Norenberg MD. Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure. Neurobiology of disease 2013. PMID: 24321433


  132. Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013. PMID: 24316107


  133. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24200884


  134. Asavapanumas N, Ratelade J, Verkman AS. Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG. Acta neuropathologica 2013. PMID: 24190619


  135. Verkman AS, Phuan PW, Asavapanumas N, Tradtrantip L. Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO. Brain pathology (Zurich, Switzerland) 2013. PMID: 24118484


  136. Katada R, Akdemir G, Asavapanumas N, Ratelade J, Zhang H, Verkman AS. Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24186965


  137. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013. PMID: 24184676


  138. Jin BJ, Ko EA, Namkung W, Verkman AS. Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds. Lab on a chip 2013. PMID: 23907501


  139. Esteva-Font C, Phuan PW, Anderson MO, Verkman AS. A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chemistry & biology 2013. PMID: 24055006


  141. Ratelade J, Asavapanumas N, Ritchie AM, Wemlinger S, Bennett JL, Verkman AS. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Acta neuropathologica 2013. PMID: 23995423


  142. Thiagarajah JR, Verkman AS. Chloride channel-targeted therapy for secretory diarrheas. Current opinion in pharmacology 2013. PMID: 23992767


  143. Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cellular microbiology 2013. PMID: 23910799


  144. Verkman AS. Diffusion in the extracellular space in brain and tumors. Physical biology 2013. PMID: 23913007


  145. Jin BJ, Thiagarajah JR, Verkman AS. Response to "Diffusion versus convection". The Journal of general physiology 2013. PMID: 23898009


  146. Rowe SM, Verkman AS. Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harbor perspectives in medicine 2013. PMID: 23818513


  148. Jin BJ, Zhang H, Binder DK, Verkman AS. Response to "When can AQP4 assist transporter-mediated K? uptake?". The Journal of general physiology 2013. PMID: 23752331


  149. Phuan PW, Zhang H, Asavapanumas N, Leviten M, Rosenthal A, Tradtrantip L, Verkman AS. C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica. Acta neuropathologica 2013. PMID: 23677375


  150. Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Mechanism-based corrector combination restores ?F508-CFTR folding and function. Nature chemical biology 2013. PMID: 23666117


  151. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS medicinal chemistry letters 2013. PMID: 23814642


  152. Tradtrantip L, Asavapanumas N, Verkman AS. Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase. Molecular pharmacology 2013. PMID: 23571414


  153. Zhang H, Verkman AS. Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. The Journal of clinical investigation 2013. PMID: 23563310


  154. Liu Y, Esteva-Font C, Yao C, Phuan PW, Verkman AS, Anderson MO. 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model. Bioorganic & medicinal chemistry letters 2013. PMID: 23597791


  155. Levin MH, Bennett JL, Verkman AS. Optic neuritis in neuromyelitis optica. Progress in retinal and eye research 2013. PMID: 23545439


  156. Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nature reviews. Neuroscience 2013. PMID: 23481483


  157. Jin BJ, Thiagarajah JR, Verkman AS. Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. The Journal of general physiology 2013. PMID: 23359285


  158. Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. British journal of pharmacology 2013. PMID: 22946562


  159. Verkman AS. Aquaporins. Current biology : CB 2013. PMID: 23347934


  160. Jin BJ, Zhang H, Binder DK, Verkman AS. Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. The Journal of general physiology 2013. PMID: 23277478


  161. Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO. CFTR inhibitors. Current pharmaceutical design 2013. PMID: 23331030


  162. Saadoun S, Bridges LR, Verkman AS, Papadopoulos MC. Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions. Neuroreport 2012. PMID: 23108041


  163. Valentine CD, Lukacs GL, Verkman AS, Haggie PM. Reduced PDZ interactions of rescued ?F508CFTR increases its cell surface mobility. The Journal of biological chemistry 2012. PMID: 23115232


  164. Tradtrantip L, Ratelade J, Zhang H, Verkman AS. Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody. Annals of neurology 2012. PMID: 23055279


  165. Phuan PW, Anderson MO, Tradtrantip L, Zhang H, Tan J, Lam C, Bennett JL, Verkman AS. A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4. The Journal of biological chemistry 2012. PMID: 22989877


  167. Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL. Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Molecular biology of the cell 2012. PMID: 22973054


  168. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y. Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. The Journal of experimental medicine 2012. PMID: 22927550


  169. Thiagarajah JR, Verkman AS. CFTR inhibitors for treating diarrheal disease. Clinical pharmacology and therapeutics 2012. PMID: 22850599


  170. Donald MB, Rodriguez KX, Shay H, Phuan PW, Verkman AS, Kurth MJ. Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis. Bioorganic & medicinal chemistry 2012. PMID: 22841006


  171. Rossi A, Moritz TJ, Ratelade J, Verkman AS. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes. Journal of cell science 2012. PMID: 22718347


  172. Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS. Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. Journal of medicinal chemistry 2012. PMID: 22694147


  173. Ratelade J, Verkman AS. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. The international journal of biochemistry & cell biology 2012. PMID: 22713791


  174. Kumar S, Namkung W, Verkman AS, Sharma PK. Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorganic & medicinal chemistry 2012. PMID: 22739085


  175. Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS. Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. PloS one 2012. PMID: 22666439


  176. Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. The Lancet. Neurology 2012. PMID: 22608667


  177. Rossi A, Ratelade J, Papadopoulos MC, Bennett JL, Verkman AS. Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22589299


  178. Ratelade J, Zhang H, Saadoun S, Bennett JL, Papadopoulos MC, Verkman AS. Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss. Acta neuropathologica 2012. PMID: 22526022


  179. Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. Journal of the American Society of Nephrology : JASN 2012. PMID: 22491419


  180. Phuan PW, Ratelade J, Rossi A, Tradtrantip L, Verkman AS. Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays. The Journal of biological chemistry 2012. PMID: 22393049


  181. Saadoun S, Waters P, MacDonald C, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Annals of neurology 2012. PMID: 22374891


  182. Tradtrantip L, Zhang H, Anderson MO, Saadoun S, Phuan PW, Papadopoulos MC, Bennett JL, Verkman AS. Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012. PMID: 22319008


  183. Tradtrantip L, Zhang H, Saadoun S, Phuan PW, Lam C, Papadopoulos MC, Bennett JL, Verkman AS. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Annals of neurology 2012. PMID: 22271321


  184. Knapp JM, Wood AB, Phuan PW, Lodewyk MW, Tantillo DJ, Verkman AS, Kurth MJ. Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein. Journal of medicinal chemistry 2012. PMID: 22214395


  185. Davison HR, Solano DM, Phuan PW, Verkman AS, Kurth MJ. Fluorinated ?F508-CFTR correctors and potentiators for PET imaging. Bioorganic & medicinal chemistry letters 2012. PMID: 22281185


  186. Verkman AS. Aquaporins in clinical medicine. Annual review of medicine 2012. PMID: 22248325


  187. Baumgart F, Rossi A, Verkman AS. Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras. The Journal of general physiology 2012. PMID: 22200949


  188. Verkman AS, Rossi A, Crane JM. Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion. Methods in enzymology 2012. PMID: 22264543


  189. Lukacs GL, Verkman AS. CFTR: folding, misfolding and correcting the ?F508 conformational defect. Trends in molecular medicine 2011. PMID: 22138491


  190. Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ. Functional fluorescently labeled bithiazole ?F508-CFTR corrector imaged in whole body slices in mice. Bioconjugate chemistry 2011. PMID: 22034937


  191. Ratelade J, Bennett JL, Verkman AS. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. The Journal of biological chemistry 2011. PMID: 22069320


  192. Zhang H, Bennett JL, Verkman AS. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. Annals of neurology 2011. PMID: 22069219


  193. Rossi A, Baumgart F, van Hoek AN, Verkman AS. Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays. Traffic (Copenhagen, Denmark) 2011. PMID: 21981006


  195. Valentine CD, Verkman AS, Haggie PM. Protein trafficking rates assessed by quantum dot quenching with bromocresol green. Traffic (Copenhagen, Denmark) 2011. PMID: 21951589


  196. Namkung W, Yao Z, Finkbeiner WE, Verkman AS. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21836025


  197. Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. Journal of medicinal chemistry 2011. PMID: 21707078


  199. Verkman AS. Aquaporins at a glance. Journal of cell science 2011. PMID: 21670197


  201. Crane JM, Rossi A, Gupta T, Bennett JL, Verkman AS. Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms. Journal of neuroimmunology 2011. PMID: 21621278


  202. Verkman AS, Ratelade J, Rossi A, Zhang H, Tradtrantip L. Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. Acta pharmacologica Sinica 2011. PMID: 21552296


  203. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011. PMID: 21525279


  204. Saadoun S, Waters P, Macdonald C, Bridges LR, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. Journal of neuroimmunology 2011. PMID: 21492943


  206. Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21427214


  207. Crane JM, Lam C, Rossi A, Gupta T, Bennett JL, Verkman AS. Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. The Journal of biological chemistry 2011. PMID: 21454592


  208. Carpenter RD, Verkman AS. Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing. European journal of organic chemistry 2011. PMID: 23914138


  209. Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21257712


  210. Nakahigashi K, Kabashima K, Ikoma A, Verkman AS, Miyachi Y, Hara-Chikuma M. Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. The Journal of investigative dermatology 2010. PMID: 21191421


  212. Wang D, Nykanen M, Yang N, Winlaw D, North K, Verkman AS, Owler BK. Altered cellular localization of aquaporin-1 in experimental hydrocephalus in mice and reduced ventriculomegaly in aquaporin-1 deficiency. Molecular and cellular neurosciences 2010. PMID: 21040788


  213. Thiagarajah JR, Song Y, Derichs N, Verkman AS. Airway surface liquid depth imaged by surface laser reflectance microscopy. The Journal of general physiology 2010. PMID: 20713545


  215. Namkung W, Thiagarajah JR, Phuan PW, Verkman AS. Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010. PMID: 20581223


  216. Namkung W, Finkbeiner WE, Verkman AS. CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. Molecular biology of the cell 2010. PMID: 20554763


  217. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Annals of neurology 2010. PMID: 20517941


  218. Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. Journal of medicinal chemistry 2010. PMID: 20373765


  219. Yu GJ, Yang B, Verkman AS, Kurth MJ. Isoxazolopyrimidines as Novel ?F508-CFTR Correctors. Synlett : accounts and rapid communications in synthetic organic chemistry 2010. PMID: 23710112


  220. Carpenter RD, Verkman AS. Synthesis of a sensitive and selective potassium-sensing fluoroionophore. Organic letters 2010. PMID: 20148571


  221. Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. Neuroscience 2010. PMID: 20132873


  223. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain : a journal of neurology 2010. PMID: 20047900


  224. Crane JM, Bennett JL, Verkman AS. Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells. The Journal of biological chemistry 2009. PMID: 19843522


  225. Zhang H, Verkman AS. Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. The Journal of biological chemistry 2009. PMID: 20018876


  227. Mills AD, Yoo C, Butler JD, Yang B, Verkman AS, Kurth MJ. Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorganic & medicinal chemistry letters 2009. PMID: 19954980


  228. Tradtrantip L, Sonawane ND, Namkung W, Verkman AS. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. Journal of medicinal chemistry 2009. PMID: 19785436


  229. Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS. Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19820035


  231. Crane JM, Tajima M, Verkman AS. Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles. Neuroscience 2009. PMID: 19699275


  232. Li L, Zhang H, Verkman AS. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. BMC neuroscience 2009. PMID: 19660138


  233. Verkman AS. Aquaporins: translating bench research to human disease. The Journal of experimental biology 2009. PMID: 19448080


  234. Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye. The Journal of biological chemistry 2009. PMID: 19364771


  235. Saadoun S, Tait MJ, Reza A, Davies DC, Bell BA, Verkman AS, Papadopoulos MC. AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology. Neuroscience 2009. PMID: 19345723


  236. Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T. Sporadic obstructive hydrocephalus in Aqp4 null mice. Journal of neuroscience research 2009. PMID: 18951529


  237. Haggie PM, Verkman AS. Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19329540


  238. Magzoub M, Zhang H, Dix JA, Verkman AS. Extracellular space volume measured by two-color pulsed dye infusion with microfiberoptic fluorescence photodetection. Biophysical journal 2009. PMID: 19289063


  239. Ruiz-Ederra J, Verkman AS. Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Experimental eye research 2009. PMID: 19298815


  240. Crane JM, Haggie PM, Verkman AS. QUANTUM DOT SINGLE MOLECULE TRACKING REVEALS A WIDE RANGE OF DIFFUSIVE MOTIONS OF MEMBRANE TRANSPORT PROTEINS. Proceedings of SPIE--the International Society for Optical Engineering 2009. PMID: 24386532


  242. Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, Miyachi Y. The expression of differentiation markers in aquaporin-3 deficient epidermis. Archives of dermatological research 2009. PMID: 19184071


  243. Li L, Zhang H, Ma T, Verkman AS. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. American journal of physiology. Gastrointestinal and liver physiology 2009. PMID: 19179619


  244. Ruiz-Ederra J, Levin MH, Verkman AS. In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency. Investigative ophthalmology & visual science 2009. PMID: 19136711


  245. Haggie PM, Verkman AS. Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. The Journal of biological chemistry 2009. PMID: 19136560


  246. Tradtrantip L, Tajima M, Li L, Verkman AS. Aquaporin water channels in transepithelial fluid transport. The journal of medical investigation : JMI 2009. PMID: 20224178


  247. Verkman AS. Knock-out models reveal new aquaporin functions. Handbook of experimental pharmacology 2009. PMID: 19096787


  248. Yang B, Zhao D, Verkman AS. Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008. PMID: 18854434


  249. Tradtrantip L, Yangthara B, Padmawar P, Morrison C, Verkman AS. Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Molecular pharmacology 2008. PMID: 18824527


  250. Yu GJ, Yoo CL, Yang B, Lodewyk MW, Meng L, El-Idreesy TT, Fettinger JC, Tantillo DJ, Verkman AS, Kurth MJ. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. Journal of medicinal chemistry 2008. PMID: 18788728


  251. Zhang H, Verkman AS. Evidence against involvement of aquaporin-4 in cell-cell adhesion. Journal of molecular biology 2008. PMID: 18708067


  252. Sonawane ND, Verkman AS. Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. Bioorganic & medicinal chemistry 2008. PMID: 18691893


  253. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chemistry & biology 2008. PMID: 18635008


  254. Haggie PM, Verkman AS. Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging. The Journal of biological chemistry 2008. PMID: 18617526


  255. Caci E, Caputo A, Hinzpeter A, Arous N, Fanen P, Sonawane N, Verkman AS, Ravazzolo R, Zegarra-Moran O, Galietta LJ. Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis. The Biochemical journal 2008. PMID: 18366345


  256. Hara-Chikuma M, Verkman AS. Roles of aquaporin-3 in the epidermis. The Journal of investigative dermatology 2008. PMID: 18548108


  257. Yang B, Zhang H, Verkman AS. Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorganic & medicinal chemistry 2008. PMID: 18572411


  258. Namkung W, Padmawar P, Mills AD, Verkman AS. Cell-based fluorescence screen for K+ channels and transporters using an extracellular triazacryptand-based K+ sensor. Journal of the American Chemical Society 2008. PMID: 18512924


  259. Lu DC, Zhang H, Zador Z, Verkman AS. Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008. PMID: 18511552


  260. Verkman AS. From the farm to the lab: the pig as a new model of cystic fibrosis lung disease. American journal of physiology. Lung cellular and molecular physiology 2008. PMID: 18502814


  261. Verkman AS, Ruiz-Ederra J, Levin MH. Functions of aquaporins in the eye. Progress in retinal and eye research 2008. PMID: 18501660


  262. Crane JM, Van Hoek AN, Skach WR, Verkman AS. Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking. Molecular biology of the cell 2008. PMID: 18495865


  263. Verkman AS. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert reviews in molecular medicine 2008. PMID: 18482462


  265. Verkman AS. Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Seminars in nephrology 2008. PMID: 18519083


  266. Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS. Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. Journal of the American Society of Nephrology : JASN 2008. PMID: 18385427


  267. Yang B, Zador Z, Verkman AS. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. The Journal of biological chemistry 2008. PMID: 18375385


  268. Yoo CL, Yu GJ, Yang B, Robins LI, Verkman AS, Kurth MJ. 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorganic & medicinal chemistry letters 2008. PMID: 18394886


  269. Verkman AS, Hara-Chikuma M, Papadopoulos MC. Aquaporins--new players in cancer biology. Journal of molecular medicine (Berlin, Germany) 2008. PMID: 18311471


  271. Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS. Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity. The Journal of pharmacology and experimental therapeutics 2008. PMID: 18272811


  272. Saadoun S, Bell BA, Verkman AS, Papadopoulos MC. Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain : a journal of neurology 2008. PMID: 18267965


  273. Verkman AS, Galietta LJ. Chloride channels as drug targets. Nature reviews. Drug discovery 2008. PMID: 19153558


  274. Dix JA, Verkman AS. Crowding effects on diffusion in solutions and cells. Annual review of biophysics 2008. PMID: 18573081


  275. Papadopoulos MC, Verkman AS. Potential utility of aquaporin modulators for therapy of brain disorders. Progress in brain research 2008. PMID: 18655912


  276. De La Fuente R, Namkung W, Mills A, Verkman AS. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Molecular pharmacology 2007. PMID: 18083779


  277. Hara-Chikuma M, Verkman AS. Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. Journal of molecular medicine (Berlin, Germany) 2007. PMID: 17968524


  278. Papadopoulos MC, Saadoun S, Verkman AS. Aquaporins and cell migration. Pflugers Archiv : European journal of physiology 2007. PMID: 17968585


  279. Hara-Chikuma M, Verkman AS. Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Molecular and cellular biology 2007. PMID: 17967887


  280. Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17965267


  281. Ruiz-Ederra J, Verkman AS. Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy. Investigative ophthalmology & visual science 2007. PMID: 17898307


  283. Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17761521


  284. Haggie PM, Verkman AS. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. The Journal of biological chemistry 2007. PMID: 17724021


  285. Zhang H, Verkman AS. Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells. Molecular and cellular neurosciences 2007. PMID: 17869537


  286. Thiagarajah JR, Zhao D, Verkman AS. Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut 2007. PMID: 17573386


  287. Ruiz-Ederra J, Zhang H, Verkman AS. Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells. The Journal of biological chemistry 2007. PMID: 17525153


  289. Yangthara B, Mills A, Chatsudthipong V, Tradtrantip L, Verkman AS. Small-molecule vasopressin-2 receptor antagonist identified by a g-protein coupled receptor "pathway" screen. Molecular pharmacology 2007. PMID: 17435162


  291. Papadopoulos MC, Verkman AS. Aquaporin-4 and brain edema. Pediatric nephrology (Berlin, Germany) 2007. PMID: 17347837


  292. Verkman AS. Role of aquaporins in lung liquid physiology. Respiratory physiology & neurobiology 2007. PMID: 17369110


  293. Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS. Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology 2007. PMID: 17408659


  294. Levin MH, de la Fuente R, Verkman AS. Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17202246


  295. Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006. PMID: 17135365


  297. Magzoub M, Padmawar P, Dix JA, Verkman AS. Millisecond association kinetics of K+ with triazacryptand-based K+ indicators measured by fluorescence correlation spectroscopy. The journal of physical chemistry. B 2006. PMID: 17048948


  298. Levin MH, Verkman AS. Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization. Investigative ophthalmology & visual science 2006. PMID: 17003427


  299. Haggie PM, Kim JK, Lukacs GL, Verkman AS. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Molecular biology of the cell 2006. PMID: 16987954


  300. De La Fuente R, Sonawane ND, Arumainayagam D, Verkman AS. Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening. British journal of pharmacology 2006. PMID: 16981005


  301. Ruiz-Ederra J, Verkman AS. Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Investigative ophthalmology & visual science 2006. PMID: 16936111


  302. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. CFTR inhibition mimics the cystic fibrosis inflammatory profile. American journal of physiology. Lung cellular and molecular physiology 2006. PMID: 16920886


  303. Levin MH, Verkman AS. Aquaporins and CFTR in ocular epithelial fluid transport. The Journal of membrane biology 2006. PMID: 16868675


  304. Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS. Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins. The Journal of biological chemistry 2006. PMID: 16829520


  305. Hu J, Verkman AS. Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006. PMID: 16818469


  306. Hara-Chikuma M, Verkman AS. Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins. Cellular and molecular life sciences : CMLS 2006. PMID: 16715408


  307. Ni J, Verbavatz JM, Rippe A, Boisdé I, Moulin P, Rippe B, Verkman AS, Devuyst O. Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney international 2006. PMID: 16508653


  308. Verkman AS. Roles of aquaporins in kidney revealed by transgenic mice. Seminars in nephrology 2006. PMID: 16713493


  309. Yang B, Zhao D, Verkman AS. Evidence against functionally significant aquaporin expression in mitochondria. The Journal of biological chemistry 2006. PMID: 16624821


  310. Yang B, Zhao D, Solenov E, Verkman AS. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. American journal of physiology. Cell physiology 2006. PMID: 16624991


  311. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 2006. PMID: 16470808


  312. Verkman AS. Aquaporins in endothelia. Kidney international 2006. PMID: 16508658


  313. Thiagarajah JR, Kim JK, Magzoub M, Verkman AS. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nature methods 2006. PMID: 16554832


  314. Butler TL, Au CG, Yang B, Egan JR, Tan YM, Hardeman EC, North KN, Verkman AS, Winlaw DS. Cardiac aquaporin expression in humans, rats, and mice. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16582023


  315. Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman AS, Cartron JP. Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2006. PMID: 16574458


  316. Bloch O, Auguste KI, Manley GT, Verkman AS. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006. PMID: 16552421


  317. Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochimica et biophysica acta 2006. PMID: 16564496


  319. Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochemical and biophysical research communications 2006. PMID: 16476579


  320. Yang B, Zhao D, Qian L, Verkman AS. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. American journal of physiology. Renal physiology 2006. PMID: 16434568


  321. Verkman AS, Lukacs GL, Galietta LJ. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Current pharmaceutical design 2006. PMID: 16787252


  322. Binder DK, Yao X, Verkman AS, Manley GT. Increased seizure duration in mice lacking aquaporin-4 water channels. Acta neurochirurgica. Supplement 2006. PMID: 16671491


  323. Levin MH, Kim JK, Hu J, Verkman AS. Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model. Investigative ophthalmology & visual science 2006. PMID: 16384978


  324. Hara-Chikuma M, Verkman AS. Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule. Journal of the American Society of Nephrology : JASN 2005. PMID: 16319186


  325. Sonawane ND, Hu J, Muanprasat C, Verkman AS. Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005. PMID: 16317066


  326. Ruiz-Ederra J, Verkman AS. Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Experimental eye research 2005. PMID: 16310189


  327. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. Journal of cell science 2005. PMID: 16303850


  328. Suen YF, Robins L, Yang B, Verkman AS, Nantz MH, Kurth MJ. Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorganic & medicinal chemistry letters 2005. PMID: 16288863


  329. Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS. K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nature methods 2005. PMID: 16278651


  330. Song Y, Salinas D, Nielson DW, Verkman AS. Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. American journal of physiology. Cell physiology 2005. PMID: 16207791


  331. Bloch O, Papadopoulos MC, Manley GT, Verkman AS. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. Journal of neurochemistry 2005. PMID: 16181429


  332. Kim SW, Gresz V, Rojek A, Wang W, Verkman AS, Frøkiaer J, Nielsen S. Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice. Biology of the cell 2005. PMID: 15898956


  333. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. American journal of physiology. Lung cellular and molecular physiology 2005. PMID: 16143588


  335. Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Molecular and cellular biology 2005. PMID: 16107722


  336. Pedemonte N, Lukacs GL, Du K, Caci E, Zegarra-Moran O, Galietta LJ, Verkman AS. Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. The Journal of clinical investigation 2005. PMID: 16127463


  337. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. The Journal of experimental medicine 2005. PMID: 16087714


  338. Verkman AS. More than just water channels: unexpected cellular roles of aquaporins. Journal of cell science 2005. PMID: 16079275


  339. Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. American journal of physiology. Renal physiology 2005. PMID: 15998844


  340. Hara-Chikuma M, Verkman AS. Aquaporin-3 functions as a glycerol transporter in mammalian skin. Biology of the cell 2005. PMID: 15966863


  341. Schulz BL, Sloane AJ, Robinson LJ, Sebastian LT, Glanville AR, Song Y, Verkman AS, Harry JL, Packer NH, Karlsson NG. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. The Biochemical journal 2005. PMID: 15563276


  342. Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS. Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochemical and biophysical research communications 2005. PMID: 15752747


  343. Thiagarajah JR, Papadopoulos MC, Verkman AS. Noninvasive early detection of brain edema in mice by near-infrared light scattering. Journal of neuroscience research 2005. PMID: 15765520


  344. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 2005. PMID: 15815633


  345. Lechardeur D, Verkman AS, Lukacs GL. Intracellular routing of plasmid DNA during non-viral gene transfer. Advanced drug delivery reviews 2005. PMID: 15757759


  346. Levin MH, Verkman AS. CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences. Investigative ophthalmology & visual science 2005. PMID: 15790911


  347. Thiagarajah JR, Verkman AS. New drug targets for cholera therapy. Trends in pharmacological sciences 2005. PMID: 15808339


  348. Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS. Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. The Journal of biological chemistry 2005. PMID: 15746100


  349. Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Molecular pharmacology 2005. PMID: 15722457


  350. Papadopoulos MC, Verkman AS. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. The Journal of biological chemistry 2005. PMID: 15695511


  351. Yang B, Song Y, Zhao D, Verkman AS. Phenotype analysis of aquaporin-8 null mice. American journal of physiology. Cell physiology 2005. PMID: 15647389


  353. Sonawane ND, Muanprasat C, Nagatani R, Song Y, Verkman AS. In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents. Journal of pharmaceutical sciences 2005. PMID: 15761937


  354. Verkman AS. Novel roles of aquaporins revealed by phenotype analysis of knockout mice. Reviews of physiology, biochemistry and pharmacology 2005. PMID: 16091927


  355. Papadopoulos MC, Binder DK, Verkman AS. Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004. PMID: 15596484


  356. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004. PMID: 15596485


  357. Da T, Verkman AS. Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. Investigative ophthalmology & visual science 2004. PMID: 15557457


  358. Levin MH, Verkman AS. Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva. Investigative ophthalmology & visual science 2004. PMID: 15557451


  359. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004. PMID: 15533949


  360. Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS. ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. The Journal of biological chemistry 2004. PMID: 15504734


  361. Binder DK, Papadopoulos MC, Haggie PM, Verkman AS. In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004. PMID: 15371505


  362. Verkman AS. Drug discovery and epithelial physiology. Current opinion in nephrology and hypertension 2004. PMID: 15300164


  364. Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. The Journal of general physiology 2004. PMID: 15277574


  365. Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS. Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models. The Journal of biological chemistry 2004. PMID: 15280357


  366. Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. American journal of physiology. Lung cellular and molecular physiology 2004. PMID: 15246976


  367. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004. PMID: 15208268


  368. Kuang K, Yiming M, Wen Q, Li Y, Ma L, Iserovich P, Verkman AS, Fischbarg J. Fluid transport across cultured layers of corneal endothelium from aquaporin-1 null mice. Experimental eye research 2004. PMID: 15037113


  369. Thiagarajah JR, Song Y, Haggie PM, Verkman AS. A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004. PMID: 15001557


  370. Verkman AS. Drug discovery in academia. American journal of physiology. Cell physiology 2004. PMID: 14761879


  371. Binder DK, Oshio K, Ma T, Verkman AS, Manley GT. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport 2004. PMID: 15076748


  372. Thiagarajah JR, Broadbent T, Hsieh E, Verkman AS. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology 2004. PMID: 14762788


  373. Taddei A, Folli C, Zegarra-Moran O, Fanen P, Verkman AS, Galietta LJ. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS letters 2004. PMID: 14759515


  374. Oshio K, Binder DK, Yang B, Schecter S, Verkman AS, Manley GT. Expression of aquaporin water channels in mouse spinal cord. Neuroscience 2004. PMID: 15283967


  375. Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. Molecular mechanisms of brain tumor edema. Neuroscience 2004. PMID: 15561416


  376. Manley GT, Binder DK, Papadopoulos MC, Verkman AS. New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience 2004. PMID: 15561413


  377. Thiagarajah JR, Verkman AS. CFTR pharmacology and its role in intestinal fluid secretion. Current opinion in pharmacology 2003. PMID: 14644010


  378. Haggie PM, Stanton BA, Verkman AS. Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif. The Journal of biological chemistry 2003. PMID: 14660592


  379. Solenov E, Watanabe H, Manley GT, Verkman AS. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. American journal of physiology. Cell physiology 2003. PMID: 14576087


  380. Song Y, Thiagarajah J, Verkman AS. Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. The Journal of general physiology 2003. PMID: 14557401


  381. Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorganic & medicinal chemistry 2003. PMID: 12927873


  382. Sonawane ND, Szoka FC, Verkman AS. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. The Journal of biological chemistry 2003. PMID: 12944394


  383. Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorganic & medicinal chemistry letters 2003. PMID: 12852954


  384. Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. The Journal of biological chemistry 2003. PMID: 12832418


  385. Hara M, Verkman AS. Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 2003. PMID: 12771381


  386. Kim YH, Kim J, Verkman AS, Madsen KM. Increased expression of H+-ATPase in inner medullary collecting duct of aquaporin-1-deficient mice. American journal of physiology. Renal physiology 2003. PMID: 12759225


  387. Sonawane ND, Verkman AS. Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands. The Journal of cell biology 2003. PMID: 12668661


  388. Caci E, Folli C, Zegarra-Moran O, Ma T, Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. American journal of physiology. Lung cellular and molecular physiology 2003. PMID: 12651632


  389. Verkman AS. Role of aquaporin water channels in eye function. Experimental eye research 2003. PMID: 12565800


  390. Oshio K, Song Y, Verkman AS, Manley GT. Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production. Acta neurochirurgica. Supplement 2003. PMID: 14753499


  391. Oshio K, Binder DK, Bollen A, Verkman AS, Berger MS, Manley GT. Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema. Acta neurochirurgica. Supplement 2003. PMID: 14753494


  392. Verkman AS. Diffusion in cells measured by fluorescence recovery after photobleaching. Methods in enzymology 2003. PMID: 12622172


  393. Verkman AS, Song Y, Thiagarajah JR. Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. American journal of physiology. Cell physiology 2003. PMID: 12475759


  394. Borok Z, Verkman AS. Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways. Journal of applied physiology (Bethesda, Md. : 1985) 2002. PMID: 12433939


  395. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. The Journal of clinical investigation 2002. PMID: 12464670


  396. Mann SE, Ricke EA, Yang BA, Verkman AS, Taylor RN. Expression and localization of aquaporin 1 and 3 in human fetal membranes. American journal of obstetrics and gynecology 2002. PMID: 12388974


  397. Mennone A, Verkman AS, Boyer JL. Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. American journal of physiology. Gastrointestinal and liver physiology 2002. PMID: 12181190


  398. Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS. Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. Journal of applied physiology (Bethesda, Md. : 1985) 2002. PMID: 12391048


  400. Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. The Journal of biological chemistry 2002. PMID: 12161441


  403. Verkman AS. Does aquaporin-1 pass gas? An opposing view. The Journal of physiology 2002. PMID: 12096046


  404. Fang X, Yang B, Matthay MA, Verkman AS. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. The Journal of physiology 2002. PMID: 12096051


  405. Zhang D, Vetrivel L, Verkman AS. Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production. The Journal of general physiology 2002. PMID: 12034763


  406. Verkman AS. Aquaporin water channels and endothelial cell function. Journal of anatomy 2002. PMID: 12162729


  407. Song Y, Sonawane N, Verkman AS. Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice. The Journal of physiology 2002. PMID: 12042359


  408. Thiagarajah JR, Verkman AS. Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. The Journal of biological chemistry 2002. PMID: 11891232


  409. Ma T, Hara M, Sougrat R, Verbavatz JM, Verkman AS. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. The Journal of biological chemistry 2002. PMID: 11880378


  411. Li J, Patil RV, Verkman AS. Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels. Investigative ophthalmology & visual science 2002. PMID: 11818406


  412. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. The Journal of general physiology 2002. PMID: 11815669


  413. Solenov EI, Vetrivel L, Oshio K, Manley GT, Verkman AS. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. Journal of neuroscience methods 2002. PMID: 11741725


  414. Yang B, Bankir L, Gillespie A, Epstein CJ, Verkman AS. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. The Journal of biological chemistry 2002. PMID: 11792714


  415. Verkman AS, Yang B. Aquaporin gene delivery to kidney. Kidney international 2002. PMID: 11841625


  416. Verkman AS, Jayaraman S. Fluorescent indicator methods to assay functional CFTR expression in cells. Methods in molecular medicine 2002. PMID: 11917522


  417. Verkman AS. Physiological importance of aquaporin water channels. Annals of medicine 2002. PMID: 12173689


  418. Verkman AS. Renal concentrating and diluting function in deficiency of specific aquaporin genes. Experimental nephrology 2002. PMID: 12097826


  419. Verkman AS. Solute and macromolecule diffusion in cellular aqueous compartments. Trends in biochemical sciences 2002. PMID: 11796221


  420. Sonawane ND, Thiagarajah JR, Verkman AS. Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. The Journal of biological chemistry 2001. PMID: 11741919


  421. Thiagarajah JR, Jayaraman S, Naftalin RJ, Verkman AS. In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. American journal of physiology. Cell physiology 2001. PMID: 11698248


  422. Zhou Q, Clarke L, Nie R, Carnes K, Lai LW, Lien YH, Verkman A, Lubahn D, Fisher JS, Katzenellenbogen BS, Hess RA. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proceedings of the National Academy of Sciences of the United States of America 2001. PMID: 11698654


  423. Jayaraman S, Song Y, Verkman AS. Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. American journal of physiology. Cell physiology 2001. PMID: 11600413


  424. Galietta LV, Jayaraman S, Verkman AS. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. American journal of physiology. Cell physiology 2001. PMID: 11600438


  425. Verkman AS. Applications of aquaporin inhibitors. Drug news & perspectives 2001. PMID: 12813584


  426. Kim YH, Earm JH, Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J. Aquaporin-4 expression in adult and developing mouse and rat kidney. Journal of the American Society of Nephrology : JASN 2001. PMID: 11518772


  427. Verkman AS. Lung disease in cystic fibrosis: is airway surface liquid composition abnormal? American journal of physiology. Lung cellular and molecular physiology 2001. PMID: 11435202


  428. Joo NS, Krouse ME, Wu JV, Saenz Y, Jayaraman S, Verkman AS, Wine JJ. HCO3- transport in relation to mucus secretion from submucosal glands. JOP : Journal of the pancreas 2001. PMID: 11875272


  429. Jayaraman S, Joo NS, Reitz B, Wine JJ, Verkman AS. Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na(+)] and pH but elevated viscosity. Proceedings of the National Academy of Sciences of the United States of America 2001. PMID: 11427704


  430. Galietta LJ, Haggie PM, Verkman AS. Green fluorescent protein-based halide indicators with improved chloride and iodide affinities. FEBS letters 2001. PMID: 11423120


  431. Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. The Journal of general physiology 2001. PMID: 11382807


  432. Jayaraman S, Song Y, Verkman AS. Airway surface liquid osmolality measured using fluorophore-encapsulated liposomes. The Journal of general physiology 2001. PMID: 11331352


  433. Levin MH, Haggie PM, Vetrivel L, Verkman AS. Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. The Journal of biological chemistry 2001. PMID: 11297561


  434. Galietta LJ, Springsteel MF, Eda M, Niedzinski EJ, By K, Haddadin MJ, Kurth MJ, Nantz MH, Verkman AS. Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. The Journal of biological chemistry 2001. PMID: 11262417


  435. Jayaraman S, Song Y, Vetrivel L, Shankar L, Verkman AS. Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH. The Journal of clinical investigation 2001. PMID: 11160155


  436. Yang B, Ma T, Verkman AS. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. The Journal of biological chemistry 2001. PMID: 11035042


  437. Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. American journal of physiology. Cell physiology 2001. PMID: 11121384


  438. Song Y, Yang B, Matthay MA, Ma T, Verkman AS. Role of aquaporin water channels in pleural fluid dynamics. American journal of physiology. Cell physiology 2000. PMID: 11078688


  439. Foster W, Helm A, Turnbull I, Gulati H, Yang B, Verkman AS, Skach WR. Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. The Journal of biological chemistry 2000. PMID: 10944517


  440. Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. The Journal of biological chemistry 2000. PMID: 11035038


  441. Verkman AS. Physiological importance of aquaporins: lessons from knockout mice. Current opinion in nephrology and hypertension 2000. PMID: 10990371


  442. Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS, Skach WR. Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Molecular biology of the cell 2000. PMID: 10982394


  443. Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA. Colon water transport in transgenic mice lacking aquaporin-4 water channels. American journal of physiology. Gastrointestinal and liver physiology 2000. PMID: 10915657


  444. Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA. Gastric acid secretion in aquaporin-4 knockout mice. American journal of physiology. Gastrointestinal and liver physiology 2000. PMID: 10915655


  445. Rao S, Verkman AS. Analysis of organ physiology in transgenic mice. American journal of physiology. Cell physiology 2000. PMID: 10898711


  446. Wiener MC, Verkman AS, Stroud RM, van Hoek AN. Mesoscopic surfactant organization and membrane protein crystallization. Protein science : a publication of the Protein Society 2000. PMID: 10933509


  448. Vallon V, Verkman AS, Schnermann J. Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. American journal of physiology. Renal physiology 2000. PMID: 10836992


  449. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. American journal of physiology. Cell physiology 2000. PMID: 10837338


  450. Jayaraman S, Verkman AS. Quenching mechanism of quinolinium-type chloride-sensitive fluorescent indicators. Biophysical chemistry 2000. PMID: 10885398


  451. Verkman AS, Matthay MA, Song Y. Aquaporin water channels and lung physiology. American journal of physiology. Lung cellular and molecular physiology 2000. PMID: 10781416


  452. Moore M, Ma T, Yang B, Verkman AS. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Experimental eye research 2000. PMID: 10870513


  453. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proceedings of the National Academy of Sciences of the United States of America 2000. PMID: 10737773


  454. Jayaraman S, Haggie P, Wachter RM, Remington SJ, Verkman AS. Mechanism and cellular applications of a green fluorescent protein-based halide sensor. The Journal of biological chemistry 2000. PMID: 10692389


  455. Masseguin C, Corcoran M, Carcenac C, Daunton NG, Güell A, Verkman AS, Gabrion J. Altered gravity downregulates aquaporin-1 protein expression in choroid plexus. Journal of applied physiology (Bethesda, Md. : 1985) 2000. PMID: 10710377


  457. Verkman AS, Yang B, Song Y, Manley GT, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Experimental physiology 2000. PMID: 10795927


  458. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature medicine 2000. PMID: 10655103


  459. van Hoek AN, Ma T, Yang B, Verkman AS, Brown D. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. American journal of physiology. Renal physiology 2000. PMID: 10662735


  460. Umenishi F, Verbavatz JM, Verkman AS. cAMP regulated membrane diffusion of a green fluorescent protein-aquaporin 2 chimera. Biophysical journal 2000. PMID: 10653816


  461. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. The Journal of biological chemistry 2000. PMID: 10644730


  462. Lukacs GL, Haggie P, Seksek O, Lechardeur D, Freedman N, Verkman AS. Size-dependent DNA mobility in cytoplasm and nucleus. The Journal of biological chemistry 2000. PMID: 10636854


  463. Verkman AS. Water permeability measurement in living cells and complex tissues. The Journal of membrane biology 2000. PMID: 10630923


  464. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-5 knockout mice. The Journal of clinical investigation 2000. PMID: 10619865


  465. Pallone TL, Edwards A, Ma T, Silldorff EP, Verkman AS. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. The Journal of clinical investigation 2000. PMID: 10642600


  466. Song Y, Ma T, Matthay MA, Verkman AS. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. The Journal of general physiology 2000. PMID: 10613915


  467. Verkman AS, Mitra AK. Structure and function of aquaporin water channels. American journal of physiology. Renal physiology 2000. PMID: 10644652


  468. Tamarappoo BK, Yang B, Verkman AS. Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus. The Journal of biological chemistry 1999. PMID: 10574954


  469. Jayaraman S, Teitler L, Skalski B, Verkman AS. Long-wavelength iodide-sensitive fluorescent indicators for measurement of functional CFTR expression in cells. The American journal of physiology 1999. PMID: 10564094


  470. Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. The Journal of biological chemistry 1999. PMID: 10400615


  471. Ma T, Verkman AS. Aquaporin water channels in gastrointestinal physiology. The Journal of physiology 1999. PMID: 10332084


  472. Dayel MJ, Hom EF, Verkman AS. Diffusion of green fluorescent protein in the aqueous-phase lumen of endoplasmic reticulum. Biophysical journal 1999. PMID: 10233100


  473. Verkman AS. Lessons on renal physiology from transgenic mice lacking aquaporin water channels. Journal of the American Society of Nephrology : JASN 1999. PMID: 10232700


  474. Mansoura MK, Biwersi J, Ashlock MA, Verkman AS. Fluorescent chloride indicators to assess the efficacy of CFTR cDNA delivery. Human gene therapy 1999. PMID: 10223721


  476. Farinas J, Verkman AS. Receptor-mediated targeting of fluorescent probes in living cells. The Journal of biological chemistry 1999. PMID: 10075643


  477. Jayaraman S, Biwersi J, Verkman AS. Synthesis and characterization of dual-wavelength Cl--sensitive fluorescent indicators for ratio imaging. The American journal of physiology 1999. PMID: 10070003


  478. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. The Journal of clinical investigation 1999. PMID: 10021464


  479. Chou CL, Knepper MA, Hoek AN, Brown D, Yang B, Ma T, Verkman AS. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. The Journal of clinical investigation 1999. PMID: 10021457


  480. Verkman AS. Green fluorescent protein as a probe to study intracellular solute diffusion. Methods in enzymology 1999. PMID: 12876777


  481. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. The American journal of physiology 1999. PMID: 9886922


  482. Verkman AS. Role of aquaporin water channels in kidney and lung. The American journal of the medical sciences 1998. PMID: 9822113


  483. Gustafson CE, Levine S, Katsura T, McLaughlin M, Aleixo MD, Tamarappoo BK, Verkman AS, Brown D. Vasopressin regulated trafficking of a green fluorescent protein-aquaporin 2 chimera in LLC-PK1 cells. Histochemistry and cell biology 1998. PMID: 9792416


  484. Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proceedings of the National Academy of Sciences of the United States of America 1998. PMID: 9689137


  485. Bai C, Biwersi J, Verkman AS, Matthay MA. A mouse model to test the in vivo efficacy of chemical chaperones. Journal of pharmacological and toxicological methods 1998. PMID: 9920533


  487. Ma T, Yang B, Matthay MA, Verkman AS. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. American journal of respiratory cell and molecular biology 1998. PMID: 9651190


  489. Tamarappoo BK, Verkman AS. Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. The Journal of clinical investigation 1998. PMID: 9593782


  491. Yang B, Verkman AS. Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway. The Journal of biological chemistry 1998. PMID: 9545259


  492. Carter EP, Olveczky BP, Matthay MA, Verkman AS. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Biophysical journal 1998. PMID: 9545071


  493. Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS. Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proceedings of the National Academy of Sciences of the United States of America 1998. PMID: 9501203


  494. Kneen M, Farinas J, Li Y, Verkman AS. Green fluorescent protein as a noninvasive intracellular pH indicator. Biophysical journal 1998. PMID: 9512054


  495. Neville DC, Rozanas CR, Tulk BM, Townsend RR, Verkman AS. Expression and characterization of the NBD1-R domain region of CFTR: evidence for subunit-subunit interactions. Biochemistry 1998. PMID: 9485388


  496. Partikian A, Olveczky B, Swaminathan R, Li Y, Verkman AS. Rapid diffusion of green fluorescent protein in the mitochondrial matrix. The Journal of cell biology 1998. PMID: 9472034


  497. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. The Journal of biological chemistry 1998. PMID: 9468475


  498. Chou CL, Ma T, Yang B, Knepper MA, Verkman AS. Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. The American journal of physiology 1998. PMID: 9486146


  500. Toriano R, Ford P, Rivarola V, Tamarappoo BK, Verkman AS, Parisi M. Reconstitution of a regulated transepithelial water pathway in cells transfected with AQP2 and an AQP1/AQP2 hybrid containing the AQP2-C terminus. The Journal of membrane biology 1998. PMID: 9435270


  501. Ma T, Yang B, Verkman AS. Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochemical and biophysical research communications 1997. PMID: 9388476


  502. Verbavatz JM, Ma T, Gobin R, Verkman AS. Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. Journal of cell science 1997. PMID: 9427293


  503. Neville DC, Rozanas CR, Price EM, Gruis DB, Verkman AS, Townsend RR. Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry. Protein science : a publication of the Protein Society 1997. PMID: 9385646


  505. Canfield MC, Tamarappoo BK, Moses AM, Verkman AS, Holtzman EJ. Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response. Human molecular genetics 1997. PMID: 9302264


  506. Carter EP, Umenishi F, Matthay MA, Verkman AS. Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung. The Journal of clinical investigation 1997. PMID: 9276723


  507. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. The Journal of clinical investigation 1997. PMID: 9276712


  508. Farinas J, Kneen M, Moore M, Verkman AS. Plasma membrane water permeability of cultured cells and epithelia measured by light microscopy with spatial filtering. The Journal of general physiology 1997. PMID: 9276754


  510. Seksek O, Biwersi J, Verkman AS. Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. The Journal of cell biology 1997. PMID: 9214387


  513. Cheng A, van Hoek AN, Yeager M, Verkman AS, Mitra AK. Three-dimensional organization of a human water channel. Nature 1997. PMID: 9177354


  515. Verkman AS, Yang B. Aquaporins and ion conductance. Science (New York, N.Y.) 1997. PMID: 9072811


  517. Thevenin BJ, Bicknese SE, Park J, Verkman AS, Shohet SB. Distance between Cys-201 in erythrocyte band 3 and the bilayer measured by single-photon radioluminescence. Biophysical journal 1996. PMID: 8913602


  518. Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS. Sharp increase in rat lung water channel expression in the perinatal period. American journal of respiratory cell and molecular biology 1996. PMID: 8918374


  519. Ma T, Yang B, Verkman AS. cDNA cloning of a functional water channel from toad urinary bladder epithelium. The American journal of physiology 1996. PMID: 8944654


  520. Biwersi J, Emans N, Verkman AS. Cystic fibrosis transmembrane conductance regulator activation stimulates endosome fusion in vivo. Proceedings of the National Academy of Sciences of the United States of America 1996. PMID: 8901608


  521. Townsend RR, Lipniunas PH, Tulk BM, Verkman AS. Identification of protein kinase A phosphorylation sites on NBD1 and R domains of CFTR using electrospray mass spectrometry with selective phosphate ion monitoring. Protein science : a publication of the Protein Society 1996. PMID: 8880910


  522. Carter EP, Matthay MA, Farinas J, Verkman AS. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. The Journal of general physiology 1996. PMID: 8882859


  526. Seksek O, Biwersi J, Verkman AS. Evidence against defective trans-Golgi acidification in cystic fibrosis. The Journal of biological chemistry 1996. PMID: 8663158


  527. Brown CR, Hong-Brown LQ, Biwersi J, Verkman AS, Welch WJ. Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein. Cell stress & chaperones 1996. PMID: 9222597


  528. Umenishi F, Verkman AS, Gropper MA. Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay. DNA and cell biology 1996. PMID: 8672243


  530. Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. The American journal of physiology 1996. PMID: 8928808


  533. Yang B, Brown D, Verkman AS. The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells. The Journal of biological chemistry 1996. PMID: 8617713


  534. Folkesson HG, Matthay MA, Frigeri A, Verkman AS. Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport. The Journal of clinical investigation 1996. PMID: 8609221


  536. Verkman AS, van Hoek AN, Ma T, Frigeri A, Skach WR, Mitra A, Tamarappoo BK, Farinas J. Water transport across mammalian cell membranes. The American journal of physiology 1996. PMID: 8772426


  537. Verkman AS. Optical methods to measure membrane transport processes. The Journal of membrane biology 1995. PMID: 8606370


  538. Verkman AS, Shi LB, Frigeri A, Hasegawa H, Farinas J, Mitra A, Skach W, Brown D, Van Hoek AN, Ma T. Structure and function of kidney water channels. Kidney international 1995. PMID: 8569068


  540. Frigeri A, Gropper MA, Umenishi F, Kawashima M, Brown D, Verkman AS. Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. Journal of cell science 1995. PMID: 8537439


  541. Mitra AK, van Hoek AN, Wiener MC, Verkman AS, Yeager M. The CHIP28 water channel visualized in ice by electron crystallography. Nature structural biology 1995. PMID: 7552739


  542. Bicknese S, Rossi M, Thevenin B, Shohet SB, Verkman AS. Anisotropy decay measurement of segmental dynamics of the anion binding domain in erythrocyte band 3. Biochemistry 1995. PMID: 7544617


  543. Katsura T, Verbavatz JM, Farinas J, Ma T, Ausiello DA, Verkman AS, Brown D. Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 1995. PMID: 7543677


  544. Emans N, Biwersi J, Verkman AS. Imaging of endosome fusion in BHK fibroblasts based on a novel fluorimetric avidin-biotin binding assay. Biophysical journal 1995. PMID: 8527685


  545. Shi LB, Skach WR, Ma T, Verkman AS. Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum. Biochemistry 1995. PMID: 7541239


  546. Brown D, Katsura T, Kawashima M, Verkman AS, Sabolic I. Cellular distribution of the aquaporins: a family of water channel proteins. Histochemistry and cell biology 1995. PMID: 7584554


  547. Frigeri A, Gropper MA, Turck CW, Verkman AS. Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proceedings of the National Academy of Sciences of the United States of America 1995. PMID: 7538665


  548. Bicknese S, Zimet D, Park J, van Hoek AN, Shohet SB, Verkman AS. Detection of water proximity to tryptophan residues in proteins by single photon radioluminescence. Biophysical chemistry 1995. PMID: 7749062


  549. Zimet DB, Thevenin BJ, Verkman AS, Shohet SB, Abney JR. Calculation of resonance energy transfer in crowded biological membranes. Biophysical journal 1995. PMID: 7787045


  551. Seksek O, Biwersi J, Verkman AS. Direct measurement of trans-Golgi pH in living cells and regulation by second messengers. The Journal of biological chemistry 1995. PMID: 7890600


  552. van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, Townsend RR, Verkman AS. Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels. Biochemistry 1995. PMID: 7532004


  553. Mitra AK, Yeager M, van Hoek AN, Wiener MC, Verkman AS. Projection structure of the CHIP28 water channel in lipid bilayer membranes at 12-A resolution. Biochemistry 1994. PMID: 7524655


  554. Valenti G, Verbavatz JM, Sabolic I, Ausiello DA, Verkman AS, Brown D. A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells. The American journal of physiology 1994. PMID: 7524336


  557. Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Proceedings of the National Academy of Sciences of the United States of America 1994. PMID: 7515184


  558. Biwersi J, Tulk B, Verkman AS. Long-wavelength chloride-sensitive fluorescent indicators. Analytical biochemistry 1994. PMID: 8059940


  559. Skach WR, Shi LB, Calayag MC, Frigeri A, Lingappa VR, Verkman AS. Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum. The Journal of cell biology 1994. PMID: 7514605


  560. Shi LB, Skach WR, Verkman AS. Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers. The Journal of biological chemistry 1994. PMID: 7511600


  561. Verbavatz JM, Van Hoek AN, Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D. A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26. Journal of cell science 1994. PMID: 7520041


  562. Hasegawa H, Lian SC, Finkbeiner WE, Verkman AS. Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining. The American journal of physiology 1994. PMID: 7513954


  563. Thevenin BJ, Periasamy N, Shohet SB, Verkman AS. Segmental dynamics of the cytoplasmic domain of erythrocyte band 3 determined by time-resolved fluorescence anisotropy: sensitivity to pH and ligand binding. Proceedings of the National Academy of Sciences of the United States of America 1994. PMID: 8127875


  564. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. The Journal of biological chemistry 1994. PMID: 7509789


  565. Ma T, Hasegawa H, Skach WR, Frigeri A, Verkman AS. Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel. The American journal of physiology 1994. PMID: 7508187


  566. Biwersi J, Verkman AS. Functional CFTR in endosomal compartment of CFTR-expressing fibroblasts and T84 cells. The American journal of physiology 1994. PMID: 7508186


  567. Ma T, Frigeri A, Skach W, Verkman AS. Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Biochemical and biophysical research communications 1993. PMID: 7505572


  568. Farinas J, Van Hoek AN, Shi LB, Erickson C, Verkman AS. Nonpolar environment of tryptophans in erythrocyte water channel CHIP28 determined by fluorescence quenching. Biochemistry 1993. PMID: 8218257


  569. Van Hoek AN, Wiener M, Bicknese S, Miercke L, Biwersi J, Verkman AS. Secondary structure analysis of purified functional CHIP28 water channels by CD and FTIR spectroscopy. Biochemistry 1993. PMID: 8218256


  570. Verbavatz JM, Brown D, Sabolic I, Valenti G, Ausiello DA, Van Hoek AN, Ma T, Verkman AS. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. The Journal of cell biology 1993. PMID: 7693713


  571. Ma T, Frigeri A, Tsai ST, Verbavatz JM, Verkman AS. Localization and functional analysis of CHIP28k water channels in stably transfected Chinese hamster ovary cells. The Journal of biological chemistry 1993. PMID: 8226786


  572. Bicknese S, Periasamy N, Shohet SB, Verkman AS. Cytoplasmic viscosity near the cell plasma membrane: measurement by evanescent field frequency-domain microfluorimetry. Biophysical journal 1993. PMID: 8241407


  573. Hasegawa H, Verkman AS. Functional expression of cAMP-dependent and independent urea transporters in Xenopus oocytes. The American journal of physiology 1993. PMID: 8396330


  574. Zhang R, van Hoek AN, Biwersi J, Verkman AS. A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k. Biochemistry 1993. PMID: 8457558


  575. Zhang R, Skach W, Hasegawa H, van Hoek AN, Verkman AS. Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28. The Journal of cell biology 1993. PMID: 8421053


  576. Kao HP, Abney JR, Verkman AS. Determinants of the translational mobility of a small solute in cell cytoplasm. The Journal of cell biology 1993. PMID: 8416987


  577. Hasegawa H, Zhang R, Dohrman A, Verkman AS. Tissue-specific expression of mRNA encoding rat kidney water channel CHIP28k by in situ hybridization. The American journal of physiology 1993. PMID: 7679251


  578. Sabolic I, Valenti G, Verbavatz JM, Van Hoek AN, Verkman AS, Ausiello DA, Brown D. Localization of the CHIP28 water channel in rat kidney. The American journal of physiology 1992. PMID: 1282299


  579. Hasegawa H, Skach W, Baker O, Calayag MC, Lingappa V, Verkman AS. A multifunctional aqueous channel formed by CFTR. Science (New York, N.Y.) 1992. PMID: 1279809


  580. Bicknese S, Shahrokh Z, Shohet SB, Verkman AS. Single photon radioluminescence. I. Theory and spectroscopic properties. Biophysical journal 1992. PMID: 1477277


  581. Shahrokh Z, Bicknese S, Shohet SB, Verkman AS. Single photon radioluminescence. II. Signal detection and biological applications. Biophysical journal 1992. PMID: 1477278


  582. Sabolic I, Wuarin F, Shi LB, Verkman AS, Ausiello DA, Gluck S, Brown D. Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase. The Journal of cell biology 1992. PMID: 1388176


  583. Periasamy N, Kao HP, Fushimi K, Verkman AS. Organic osmolytes increase cytoplasmic viscosity in kidney cells. The American journal of physiology 1992. PMID: 1415675


  584. Zen K, Biwersi J, Periasamy N, Verkman AS. Second messengers regulate endosomal acidification in Swiss 3T3 fibroblasts. The Journal of cell biology 1992. PMID: 1382079


  585. van Hoek AN, Verkman AS. Functional reconstitution of the isolated erythrocyte water channel CHIP28. The Journal of biological chemistry 1992. PMID: 1526967


  586. Echevarria M, Verkman AS. Optical measurement of osmotic water transport in cultured cells. Role of glucose transporters. The Journal of general physiology 1992. PMID: 1597679


  587. Periasamy N, Verkman AS. Subtraction of background fluorescence in multiharmonic frequency-domain fluorimetry. Analytical biochemistry 1992. PMID: 1621947


  588. Hartmann T, Kondo M, Mochizuki H, Verkman AS, Widdicombe JH. Calcium-dependent regulation of Cl secretion in tracheal epithelium. The American journal of physiology 1992. PMID: 1311517


  590. Sabolic I, Shi LB, Brown D, Ausiello DA, Verkman AS. Proteinases inhibit H(+)-ATPase and Na+/H+ exchange but not water transport in apical and endosomal membranes from rat proximal tubule. Biochimica et biophysica acta 1992. PMID: 1309658


  591. Hartmann T, Verkman AS. Construction and performance of a rapid scan monochromator for multiwavelength fluorimetry. Analytical biochemistry 1992. PMID: 1595888


  592. Verkman AS, Chao AC, Hartmann T. Hormonal regulation of Cl transport in polar airway epithelia measured by a fluorescent indicator. The American journal of physiology 1992. PMID: 1310213


  593. Biwersi J, Farah N, Wang YX, Ketcham R, Verkman AS. Synthesis of cell-impermeable Cl-sensitive fluorescent indicators with improved sensitivity and optical properties. The American journal of physiology 1992. PMID: 1370743


  594. Verkman AS. Water channels in cell membranes. Annual review of physiology 1992. PMID: 1373280


  595. Periasamy N, Armijo M, Verkman AS. Picosecond rotation of small polar fluorophores in the cytosol of sea urchin eggs. Biochemistry 1991. PMID: 1751500


  596. Zhang R, Alper SL, Thorens B, Verkman AS. Evidence from oocyte expression that the erythrocyte water channel is distinct from band 3 and the glucose transporter. The Journal of clinical investigation 1991. PMID: 1939644


  597. Biwersi J, Verkman AS. Cell-permeable fluorescent indicator for cytosolic chloride. Biochemistry 1991. PMID: 1868062


  598. Shi LB, Fushimi K, Verkman AS. Solvent drag measurement of transcellular and basolateral membrane NaCl reflection coefficient in kidney proximal tubule. The Journal of general physiology 1991. PMID: 1940854


  599. Kuwahara M, Shi LB, Marumo F, Verkman AS. Transcellular water flow modulates water channel exocytosis and endocytosis in kidney collecting tubule. The Journal of clinical investigation 1991. PMID: 1864956


  600. Verkman AS, Shi LB, Bae HR, Fushimi K. Transport mechanisms in kidney proximal tubule examined using chloride-sensitive fluorescent indicators. Kidney international. Supplement 1991. PMID: 1890794


  601. Shahrokh Z, Verkman AS, Shohet SB. Distance between skeletal protein 4.1 and the erythrocyte membrane bilayer measured by resonance energy transfer. The Journal of biological chemistry 1991. PMID: 2050702


  606. Fushimi K, Verkman AS. Low viscosity in the aqueous domain of cell cytoplasm measured by picosecond polarization microfluorimetry. The Journal of cell biology 1991. PMID: 1993739


  607. Fushimi K, Verkman AS. Relationship between vasopressin-sensitive water transport and plasma membrane fluidity in kidney collecting tubule. The American journal of physiology 1991. PMID: 1987773


  608. Zhang RB, Verkman AS. Water and urea permeability properties of Xenopus oocytes: expression of mRNA from toad urinary bladder. The American journal of physiology 1991. PMID: 1987778


  610. Lencer WI, Brown D, Ausiello DA, Verkman AS. Endocytosis of water channels in rat kidney: cell specificity and correlation with in vivo antidiuresis. The American journal of physiology 1990. PMID: 1701969


  611. Shi LB, Wang YX, Verkman AS. Regulation of the formation and water permeability of endosomes from toad bladder granular cells. The Journal of general physiology 1990. PMID: 1979609


  612. Zhang RB, Logee KA, Verkman AS. Expression of mRNA coding for kidney and red cell water channels in Xenopus oocytes. The Journal of biological chemistry 1990. PMID: 2394728


  613. Verkman AS. Development and biological applications of chloride-sensitive fluorescent indicators. The American journal of physiology 1990. PMID: 2205105


  614. Zhang RB, Verkman AS. Urea transport in freshly isolated and cultured cells from rat inner medullary collecting duct. The Journal of membrane biology 1990. PMID: 2172546


  615. Lencer WI, Verkman AS, Arnaout MA, Ausiello DA, Brown D. Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. The Journal of cell biology 1990. PMID: 1696262


  617. Shi LB, Brown D, Verkman AS. Water, proton, and urea transport in toad bladder endosomes that contain the vasopressin-sensitive water channel. The Journal of general physiology 1990. PMID: 2163434


  618. Roe JN, Szoka FC, Verkman AS. Fibre optic sensor for the detection of potassium using fluorescence energy transfer. The Analyst 1990. PMID: 2363517


  619. Shi LB, Ye RG, Lencer WI, Verkman AS. [Characterization of proton pump and osmotic water transport in endocytic vesicles from rat kidney proximal tubule]. Sheng li xue bao : [Acta physiologica Sinica] 1990. PMID: 2142810


  623. Lencer WI, Weyer P, Verkman AS, Ausiello DA, Brown D. FITC-dextran as a probe for endosome function and localization in kidney. The American journal of physiology 1990. PMID: 1689545


  625. Brown D, Verkman A, Skorecki K, Ausiello D. The cellular action of antidiuretic hormone. Methods in enzymology 1990. PMID: 2074776


  626. Verkman AS, Weyer P, Brown D, Ausiello DA. Functional water channels are present in clathrin-coated vesicles from bovine kidney but not from brain. The Journal of biological chemistry 1989. PMID: 2573601


  627. Chao AC, Dix JA, Sellers MC, Verkman AS. Fluorescence measurement of chloride transport in monolayer cultured cells. Mechanisms of chloride transport in fibroblasts. Biophysical journal 1989. PMID: 2482083


  628. Shi LB, Verkman AS. Very high water permeability in vasopressin-induced endocytic vesicles from toad urinary bladder. The Journal of general physiology 1989. PMID: 2515241


  629. Verkman AS. Mechanisms and regulation of water permeability in renal epithelia. The American journal of physiology 1989. PMID: 2688434


  630. Kuwahara M, Verkman AS. Pre-steady-state analysis of the turn-on and turn-off of water permeability in the kidney collecting tubule. The Journal of membrane biology 1989. PMID: 2795641


  631. Holmberg EG, Verkman AS, Dix JA. Mechanism of acridine orange interaction with phospholipids and proteins in renal microvillus vesicles. Biophysical chemistry 1989. PMID: 2804243


  632. Roe JN, Szoka FC, Verkman AS. Optical measurement of aqueous potassium concentration by a hydrophobic indicator in lipid vesicles. Biophysical chemistry 1989. PMID: 2804247


  635. Verkman AS, Takla R, Sefton B, Basbaum C, Widdicombe JH. Quantitative fluorescence measurement of chloride transport mechanisms in phospholipid vesicles. Biochemistry 1989. PMID: 2765484


  636. Ye RG, Shi LB, Lencer WI, Verkman AS. Functional colocalization of water channels and proton pumps in endosomes from kidney proximal tubule. The Journal of general physiology 1989. PMID: 2472463


  637. Verkman AS, Sellers MC, Chao AC, Leung T, Ketcham R. Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications. Analytical biochemistry 1989. PMID: 2751097


  639. Illsley NP, Glaubensklee C, Davis B, Verkman AS. Chloride transport across placental microvillous membranes measured by fluorescence. The American journal of physiology 1988. PMID: 3202148


  640. Illsley NP, Goodman JG, Verkman AS, Davis B. Macromolecule entrapment in human placental microvillous membrane vesicles. Analytical biochemistry 1988. PMID: 2469349


  642. Berry CA, Verkman AS. Osmotic gradient dependence of osmotic water permeability in rabbit proximal convoluted tubule. The Journal of membrane biology 1988. PMID: 2852255


  644. Fong P, Illsley NP, Widdicombe JH, Verkman AS. Chloride transport in apical membrane vesicles from bovine tracheal epithelium: characterization using a fluorescent indicator. The Journal of membrane biology 1988. PMID: 3210223


  645. Verkman AS, Masur SK. Very low osmotic water permeability and membrane fluidity in isolated toad bladder granules. The Journal of membrane biology 1988. PMID: 3145339


  646. Kim YK, Illsley NP, Verkman AS. Rapid fluorescence assay of glucose and neutral solute transport using an entrapped volume indicator. Analytical biochemistry 1988. PMID: 3189785


  649. Verkman AS, Lencer WI, Brown D, Ausiello DA. Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel. Nature 1988. PMID: 3368004


  651. Krapf R, Illsley NP, Tseng HC, Verkman AS. Structure-activity relationships of chloride-sensitive fluorescent indicators for biological application. Analytical biochemistry 1988. PMID: 3369678


  653. Chen PY, Illsley NP, Verkman AS. Renal brush-border chloride transport mechanisms characterized using a fluorescent indicator. The American journal of physiology 1988. PMID: 3337241


  654. Ausiello DA, Verkman AS, Skorecki KL. Vasopressin-sensitive adenylate cyclase: subunit interactions assessed by target analysis and computer modelling. Kidney international. Supplement 1987. PMID: 3126336


  655. Verkman AS. Passive H+/OH- permeability in epithelial brush border membranes. Journal of bioenergetics and biomembranes 1987. PMID: 2826411


  657. Wong KR, Verkman AS. Human platelet diffusional water permeability measured by nuclear magnetic resonance. The American journal of physiology 1987. PMID: 3591932


  658. Chen PY, Verkman AS. Non-electrolyte transport across renal proximal tubule cell membranes measured by tracer efflux and light scattering. Pflugers Archiv : European journal of physiology 1987. PMID: 3110738


  661. Illsley NP, Verkman AS. Membrane chloride transport measured using a chloride-sensitive fluorescent probe. Biochemistry 1987. PMID: 3567167


  662. Ausiello DA, Skorecki KL, Verkman AS, Bonventre JV. Vasopressin signaling in kidney cells. Kidney international 1987. PMID: 2951552


  664. Illsley NP, Lin HY, Verkman AS. Lipid domain structure correlated with membrane protein function in placental microvillus vesicles. Biochemistry 1987. PMID: 3828317


  665. Meyer MM, Verkman AS. Evidence for water channels in renal proximal tubule cell membranes. The Journal of membrane biology 1987. PMID: 3599063


  666. Chen PY, Verkman AS. Renal basolateral membrane anion transporter characterized by a fluorescent disulfonic stilbene. The Journal of membrane biology 1987. PMID: 2448466


  667. Ives HE, Chen PY, Verkman AS. Mechanism of coupling between Cl- and OH- transport in renal brush-border membranes. Biochimica et biophysica acta 1986. PMID: 3778914


  669. Cabrini G, Illsley NP, Verkman AS. External anions regulate stilbene-sensitive proton transport in placental brush border vesicles. Biochemistry 1986. PMID: 3024705


  670. Meyer MM, Verkman AS. Human platelet osmotic water and nonelectrolyte transport. The American journal of physiology 1986. PMID: 3766720


  671. Verkman AS, Skorecki KL, Jung CY, Ausiello DA. Target molecular weights for red cell band 3 stilbene and mercurial binding sites. The American journal of physiology 1986. PMID: 3020989


  672. Verkman AS, Ausiello DA, Jung CY, Skorecki KL. Mechanisms of nonhormonal activation of adenylate cyclase based on target analysis. Biochemistry 1986. PMID: 3768298


  674. Verkman AS, Ives HE. Water permeability and fluidity of renal basolateral membranes. The American journal of physiology 1986. PMID: 3963203


  675. Verkman AS, Fraser CL. Water and nonelectrolyte permeability in brain synaptosomes isolated from normal and uremic rats. The American journal of physiology 1986. PMID: 3946644


  676. Dix JA, Verkman AS, Solomon AK. Binding of chloride and a disulfonic stilbene transport inhibitor to red cell band 3. The Journal of membrane biology 1986. PMID: 3701841


  677. Skorecki KL, Verkman AS, Jung CY, Ausiello DA. Evidence for vasopressin activation of adenylate cyclase by subunit dissociation. The American journal of physiology 1986. PMID: 3942202


  678. Cabrini G, Verkman AS. Mechanism of interaction of the cyanine dye diS-C3-(5) with renal brush-border vesicles. The Journal of membrane biology 1986. PMID: 3723592


  679. Cabrini G, Verkman AS. Potential-sensitive response mechanism of diS-C3-(5) in biological membranes. The Journal of membrane biology 1986. PMID: 3761361


  680. Verkman AS, Lukacovic MF, Tinklepaugh MS, Dix JA. Quenching of red cell tryptophan fluorescence by mercurial compounds. Membrane biochemistry 1986. PMID: 3574139


  681. Verkman AS, Skorecki KL, Ausiello DA. Radiation inactivation of multimeric enzymes: application to subunit interactions of adenylate cyclase. The American journal of physiology 1986. PMID: 3942201


  682. Illsley NP, Verkman AS. Serial permeability barriers to water transport in human placental vesicles. The Journal of membrane biology 1986. PMID: 2435911


  683. Skorecki KL, Verkman AS, Ausiello DA. Vasopressin receptor-adenylate cyclase interactions. Studies in an intact cultured renal epithelial cell line (LLC-PK1). Mineral and electrolyte metabolism 1986. PMID: 3007962


  684. Dix JA, Ausiello DA, Jung CY, Verkman AS. Target analysis studies of red cell water and urea transport. Biochimica et biophysica acta 1985. PMID: 2998469


  686. Ives HE, Verkman AS. Effects of membrane fluidizing agents on renal brush border proton permeability. The American journal of physiology 1985. PMID: 4073275


  687. Verkman AS, Dix JA, Seifter JL, Skorecki KL, Jung CY, Ausiello DA. Radiation inactivation studies of renal brush border water and urea transport. The American journal of physiology 1985. PMID: 3934983


  688. Forman SA, Verkman AS, Dix JA, Solomon AK. n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate. Biochemistry 1985. PMID: 4074663


  689. Verkman AS, Dix JA, Seifter JL. Water and urea transport in renal microvillus membrane vesicles. The American journal of physiology 1985. PMID: 3993788


  690. Lukacovic MF, Verkman AS, Dix JA, Solomon AK. Specific interaction of the water transport inhibitor, pCMBS, with band 3 in red blood cell membranes. Biochimica et biophysica acta 1984. PMID: 6093883


  691. Verkman AS, Dix JA. Effect of unstirred layers on binding and reaction kinetics at a membrane surface. Analytical biochemistry 1984. PMID: 6517306


  692. Verkman AS, Skorecki K, Ausiello DA. Radiation inactivation of oligomeric enzyme systems: theoretical considerations. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6582472


  693. Verkman AS, Dix JA, Solomon AK. Anion transport inhibitor binding to band 3 in red blood cell membranes. The Journal of general physiology 1983. PMID: 6842178


  694. Solomon AK, Chasan B, Dix JA, Lukacovic MF, Toon MR, Verkman AS. The aqueous pore in the red cell membrane: band 3 as a channel for anions, cations, nonelectrolytes, and water. Annals of the New York Academy of Sciences 1983. PMID: 6322657


  695. Verkman AS, Solomon AK. A stepwise mechanism for the permeation of phloretin through a lipid bilayer. The Journal of general physiology 1982. PMID: 7142954


  696. Forman SA, Verkman AS, Dix JA, Solomon AK. Interaction of phloretin with the anion transport protein of the red blood cell membrane. Biochimica et biophysica acta 1982. PMID: 7126563


  697. Verkman AS, Dix JA, Pandiscio AA. A simple stopped-flow temperature-jump apparatus. Analytical biochemistry 1981. PMID: 7316188


  699. Verkman AS, Solomon AK. Kinetics of phloretin binding to phosphatidylcholine vesicle membranes. The Journal of general physiology 1980. PMID: 7391812


  700. Verkman AS, Pandiscio AA, Jennings M, Solomon AK. An improved temperature-jump apparatus. Analytical biochemistry 1980. PMID: 7356153


  701. Dix JA, Verkman AS, Solomon AK, Cantley LC. Human erythrocyte anion exchange site characterised using a fluorescent probe. Nature 1979. PMID: 503233