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Seeking Safety is an evidence-informed intervention adapted by HIV experts and community members to support people with HIV who are affected by trauma and/or addiction. Designed to be safe, optimistic, and empowering, Seeking Safety helps clients focus on the impact of trauma in the present rather than revisiting past experiences. The intervention also meets clients where they are along the continuum of substance use, offering an engaging and flexible approach to care.

This Implementation Guide was developed through the Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV (E2i) initiative, which tested Seeking Safety in Health Resources and Services Administration’s (HRSA) Ryan White HIV/AIDS Program (RWHAP) settings. The guide provides tools, tips, and resources to support replication of Seeking Safety in RWHAP and other HIV service organizations.

Download the Seeking Safety Implementation Guide

Cognitive Processing Therapy (CPT) is an evidence-based intervention that helps improve health outcomes for people with HIV who are also living with posttraumatic stress disorder (PTSD). Adapted by HIV experts in collaboration with community members, CPT uses cognitive behavioral therapy techniques to reduce PTSD symptoms. Through structured sessions with a behavioral health therapist, clients learn to recognize and address the impact of trauma on their thoughts, emotions, and overall well-being.

This Implementation Guide was developed as part of the Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV (E2i) initiative, which tested CPT in Health Resources and Services Administration’s (HRSA) Ryan White HIV/AIDS Program (RWHAP) settings and evaluated its effectiveness.

The guide provides practical tools, tips, and resources to support replication of CPT in RWHAP and other HIV service organizations.

Download the CPT Implementation Guide.

TIA/CHANGE is an evidence-informed intervention designed to improve health outcomes among people with HIV by helping organizations adopt a trauma-informed approach to care. Using a strengths-based model, TIA/CHANGE provides guidance and structure for organizations to understand, recognize, and respond to the effects of trauma in HIV service delivery.

This Implementation Guide was developed through the Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV (E2i) initiative, which tested TIA/CHANGE within Health Resources and Services Administration’s (HRSA) Ryan White HIV/AIDS Program (RWHAP) settings and evaluated its impact.

The guide includes practical tools, tips, and resources to support replication of TIA/CHANGE in RWHAP and other HIV service organizations.

Download the TIA/CHANGE Implementation Guide

Collaborative Care Management (CoCM) is an integrated behavioral health intervention that improves outcomes for people with HIV experiencing depression and other common psychiatric disorders. In this team-based model, a primary care provider, behavioral health care manager, and psychiatric consultant work together using validated measures and a client registry to track progress and improve care.

The Implementation Guide—developed through Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV (E2i)—provides practical tools, resources, and step-by-step guidance to replicate CoCM in Ryan White HIV/AIDS Program (RWHAP) settings and other HIV service organizations.

Download the CoCM Implementation Guide

This intervention integrates buprenorphine treatment for opioid use disorder directly into HIV primary care settings. By addressing both conditions in one location, the program helps reduce opioid use and overdose while improving engagement in HIV care.

The Implementation Guide—developed as part of Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV (E2i)—offers practical steps, tools, and resources to support replication of integrated buprenorphine treatment in Ryan White HIV/AIDS Program (RWHAP) settings and other HIV service organizations.

Download the Buprenorphine Treatment Implementation Guide