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Facilitated by The Twinning Center, the UCSF School of Nursing has partnered with the Ministry of Health in Mozambique in order to adapt, pilot, and implement an US evidence-based Positive Prevention (PP) intervention within rural Mozambique. The purpose of this project is to develop a PP intervention that will effectively address the needs of people living with HIV (PLHIV) in Mozambique through advancing understanding among healthcare providers, counseling and testing staff, and peer educators. Beginning in 2006, this intervention is taking place in two sites in Maputo Province in Mozambique. The first site focuses on building healthcare provider skills around effective risk assessment and prevention messages for their HIV-infected patients. The second site focuses on implementing similar needs assessment and prevention messages within one community–based Voluntary counseling and testing center and an accompanying peer support group. Collaboration among US and Mozambican partners (including healthcare providers, counseling and testing counselors, and PLHIV peer counselors) has guided the development of this PP intervention. The intervention currently includes case studies developed by Mozambican partners and a peer-led support group with enhanced one-to-one risk reduction counseling by counselors and PLHIV peers. Case studies are used in each setting to illustrate concepts such as assessment of transmission risk, behavioral risk reduction approaches, encouragement of partner testing and disclosure, prevention of mother-to-child transmission, and family planning.

In China, sexual transmission has become the major driving force behind the HIV epidemic, accounting for more than half (52%) of the estimated 700,000 people currently living with HIV. Men who have sex with men (MSM) may contribute to the rapid acceleration of the epidemic throughout China. Studies with Chinese MSM have documented an increasing HIV prevalence, a high HIV incidence, and high rates of unprotected intercourse and sexually transmitted infections (e.g., syphilis) known to facilitate sexual transmission of HIV. Moreover, our work found that HIV-transmission risk behavior is highly prevalent among HIV-positive MSM in China. Nonetheless, no HIV prevention interventions have targeted HIV-positive Chinese MSM. Several interventions have demonstrated efficacy in reducing sexual risk behaviors among HIV-positive MSM in the U.S. Adapting such interventions for HIV-positive MSM in China would help accelerate the process of developing an efficacious intervention for this risk group. The proposed three-year study (R34) will adapt and pilot-test currently available evidence-based behavioral interventions to reduce HIV-transmission risk behavior among HIV-positive MSM in Chongqing, China. This study will be implemented in five phases, guided by Wainberg et al.’s intervention adaptation model. In Step 1, we will identify core components of efficacious interventions (e.g., key theoretical constructs, intervention messages, delivery modes) through the review of the literature. In Step 2, we will explore cultural, psychosocial, and contextual factors associated with sexual risk behaviors and generate ideas for intervention strategies for HIV-positive MSM by conducting 15 key informant interviews with individuals knowledgeable about HIV-positive MSM and 30 in-depth interviews with HIV positive MSM. In Step 3, we will adapt efficacious interventions through reviewing the core elements of efficacious interventions identified in Step 1 and collating those elements with qualitative data collected in Step 2 with an intervention adaptation working group of 10 health professionals and MSM lay workers who serve HIV-positive MSM. In Step 4, we will pilot-test the adapted intervention with 16 HIV-positive MSM and refine the intervention if necessary. In Step 5, we will test the feasibility of implementing and assessing the intervention refined in Step 4 by conducting the intervention with 50 HIV-positive MSM and having these 50 men complete baseline and 3-month surveys.

The overall goal of this study is to enhance the physical and mental health of rural Indian women living with AIDS and their children. We will achieve these goals through the use of trained village women as Accredited Social Health Activists (ASHA) to enhance the health of women and children through improved ART adherence, CD4 levels, and physical and mental health. This Indo-US collaboration between University of California, Los Angeles, University of California, San Francisco and All India Institutes of Medical Sciences (AIIMS) builds on our previous work with rural women living with AIDS and our successful ASHA program. Specific objectives include: Using a 2x2 factorial design, we plan to assess the effects of nutrition training and/or food supplements on primary outcomes for rural women living with AIDS in improving body composition and immune status (CD4 levels) as assessed at 6-, 12- and 18-month follow-up. Examining the effects of the program arms and their interaction on adherence to ART, psychological health, nutritional adequacy, and lipid profile over time.

This is a three-phase study to identify the specific mechanisms by which MSM stigma affect sexual risk behaviors among MSM in Beijing, China.

• In Phase 1, we will explore the range of management strategies used to cope with MSM stigma via 30 in-depth qualitative interviews with MSM.
• In Phase 2, we will develop, using Phase 1 qualitative data and adapting existing quantitative scales, culturally-relevant measures of explanatory constructs of interest (e.g., MSM stigma management) to establish reliability and validity (N=170).
• In Phase 3, we will examine potential mediators (e.g., stigma management strategies, psychological distress, sexual contexts/situations) that explain how MSM stigma are linked to sexual risk for HIV with a respondent-driven sample of 500 MSM who will complete baseline and two follow-up assessments at 6 and 12 months.

We will also conduct 20 in-depth qualitative individual interviews with a subset of men selected from the Phase-3 participants to examine the acceptability of potential intervention components to address the link between MSM stigma and HIV risk.

This study aims to meet the need for in-depth formative research to develop an evidence-based and theory-driven HIV prevention intervention with MSM in Nepal. The study will be conducted in collaboration with the Blue Diamond Society, the only CBO currently serving MSM in Nepal. We will conduct five interviews with key informants who are service providers knowledgeable about HIV risk among MSM to identify sub-populations of MSM, gather initial HIV risk data, assist in the refinement of an interview guide for MSM and assess feasibility of a larger study. Based on this data, we will conduct in-depth interviews with 20 MSM to explore identity, sexual networks, risk perception and stigma. Finally, we will conduct interviews with five key informants who are leaders in HIV prevention among MSM in Nepal and South Asia. These last interviews will help the research team develop relationships with leaders in South Asian MSM HIV prevention and assess feasibility for a larger study. We will engage community members at the beginning and end of this study for their input and engagement as potential community advisory board members in a future study.